NADase
NADase structure
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Common Name | NADase | ||
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| CAS Number | 9032-65-9 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
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CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells.
J. Biol. Chem. 288(36) , 25938-49, (2013) NAD(+) is mainly synthesized in human cells via the "salvage" pathways starting from nicotinamide, nicotinic acid, or nicotinamide riboside (NR). The inhibition with FK866 of the enzyme nicotinamide phosphoribosyltransferase (NAMPT), catalyzing the first reac... |
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A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157.
Arch. Biochem. Biophys. 564 , 156-63, (2014) hCD157 catalyzes the hydrolysis of nicotinamide riboside (NR) and nicotinic acid riboside (NAR). The release of nicotinamide or nicotinic acid from NR or NAR was confirmed by spectrophotometric, HPLC and NMR analyses. hCD157 is inactivated by a mechanism-base... |
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[Therapeutic monoclonal antibodies against multiple myeloma].
Nihon Rinsho. 73(1) , 119-23, (2015) Multiple myeloma (MM) remains mostly incurable despite the recent progress in the treatment strategy. One of novel fields for anti-MM therapeutic strategy is the development of immunotherapy using monoclonal antibodies (MoAbs) against myeloma-specific antigen... |
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Contribution of adenosine-producing ectoenzymes to the mechanisms underlying the mitigation of maternal-fetal conflicts.
J. Biol. Regul. Homeost. Agents 27(2) , 519-29, (2013) The interactions taking place between mother and embryo have been the focus of detailed studies in recent years, where pregnancy is considered as an in vivo transplant. The immune systems of the mother and the embryo together establish a condition of toleranc... |
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Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS.
Proc. Natl. Acad. Sci. U. S. A. 110(24) , 9794-9, (2013) ADP-ribosylation is a posttranslational modification that modulates the functions of many target proteins. We previously showed that the fungal toxin brefeldin A (BFA) induces the ADP-ribosylation of C-terminal-binding protein-1 short-form/BFA-ADP-ribosylatio... |
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Two-pore channels function in calcium regulation in sea star oocytes and embryos.
Development 141(23) , 4598-609, (2014) Egg activation at fertilization is an excellent process for studying calcium regulation. Nicotinic acid adenine dinucleotide-phosphate (NAADP), a potent calcium messenger, is able to trigger calcium release, likely through two-pore channels (TPCs). Concomitan... |
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Intracellular NAADP increase induced by extracellular NAADP via the P2Y11-like receptor.
Biochem. Biophys. Res. Commun. 436(2) , 199-203, (2013) The aim of the study was to identify a signalling pathway allowing NAADP-induced intracellular NAADP increase and involving the P2Y11-like receptor. P2Y11-like and β-adrenergic receptors may play important regulatory roles within the cardiovascular system. Bo... |
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NAADP Mediates Insulin-Stimulated Glucose Uptake and Insulin Sensitization by PPARγ in Adipocytes
Cell Rep. 2(6) , 1607-19, (2012) Insulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Peroxisome proliferator-activated receptor γ (PPARγ) enhances insulin sensitivity. Here, we demonstrate that insulin stimulates GLUT4 and GLUT1 translocation, and glucose... |
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[CD38 and autism spectrum disorders].
No To Hattatsu. 45(6) , 431-5, (2013) We have demonstrated that CD38, a transmembrane protein with ADP-ribosyl cyclase activity, plays a critical role in mouse social behavior by regulating the release of oxytocin (OXT), which is essential for mutual recognition. When CD38 was disrupted, social a... |
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Schistosoma mansoni NAD(+) catabolizing enzyme: identification of key residues in catalysis.
Biochim. Biophys. Acta 1834(12) , 2520-7, (2013) Schistosoma mansoni NAD(+) catabolizing enzyme (SmNACE), a distant homolog of mammalian CD38, shows significant structural and functional analogy to the members of the CD38/ADP-ribosyl cyclase family. The hallmark of SmNACE is the lack of ADP-ribosyl cyclase ... |