N6-Monobutyryladenosine 3′:5′-cyclic monophosphate sodium salt
N6-Monobutyryladenosine 3′:5′-cyclic monophosphate sodium salt structure
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Common Name | N6-Monobutyryladenosine 3′:5′-cyclic monophosphate sodium salt | ||
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| CAS Number | 70253-67-7 | Molecular Weight | 421.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H17N5NaO7P | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Protein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropin.
Mol. Pharmacol. 76 , 1123-1129, (2009) Thyrotropin (TSH) regulates thyroid cell proliferation and function through cAMP-mediated signaling pathways that activate protein kinase A (PKA) and Epac/Rap1. The respective roles of PKA versus Epac/Rap1 in TSH signaling remain unclear. We set out to determ... |
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Cryptic receptors for insulin-like growth factor II in the plasma membrane of rat adipocytes--a possible link to cellular insulin resistance.
Biochim. Biophys. Acta 1282(1) , 57-62, (1996) To further elucidate the mechanisms for short-term regulation of the receptor for insulin-like growth factor II (IGF-II), we investigated effects of insulin, cAMP and phosphatase inhibitors on cell surface 125I-IGF-II binding in rat adipocytes. Preincubation ... |
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Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in human WISH cells.
Am. J. Obstet. Gynecol. 188(4) , 997-1001, (2003) Water absorption across the fetal chorioamniotic membranes is a critical regulatory pathway for amniotic fluid volume homeostasis. Aquaporins are cell membrane proteins that significantly enhance membrane permeability to water by acting as water channels. We ... |
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Abnormal adenosine 3'.5'-monophosphate stimulation of renal 1,25-dihydroxyvitamin D production in hyp mice: evidence that 25-hydroxyvitamin D-1 alpha-hydroxylase dysfunction results from aberrant intracellular function.
Endocrinology 124(3) , 1184-9, (1989) Previously we have established that abnormal regulation of renal 25-hydroxyvitamin D (25OHD)-1 alpha-hydroxylase in Hyp mice involves the PTH-adenylate cyclase component of enzyme activation. However, it remains unknown if the muted effects of PTH result from... |
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Acquisition of a transcriptionally permissive state during the 1-cell stage of mouse embryogenesis.
Dev. Biol. 149(2) , 457-62, (1992) Zygotic gene transcription initiates during the 2-cell stage of mouse embryogenesis. To learn more of the nature and timing of events leading up to transcriptional activation, we evaluated the ability of enucleated 1-cell-stage embryos to support transcriptio... |
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The insulin-like effect of growth hormone on insulin-like growth factor II receptors is opposed by cyclic AMP. Evidence for a common post-receptor pathway for growth hormone and insulin action.
Biochem. J. 268(2) , 353-7, (1990) The counter-regulatory effects of beta-adrenergic stimulation and cyclic AMP on the insulin-like action of growth hormone (GH) on the subcellular distribution of insulin-like growth factor II (IGF-II) receptors were studied in fat cells from hypophysectomized... |
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The response of 21-hydroxylase messenger ribonucleic acid levels to adenosine 3',5'-monophosphate and 12-O-tetradecanoylphorbol-13-acetate in bovine adrenocortical cells is dependent on culture conditions.
Endocrinology 128(1) , 604-10, (1991) The regulation of 21-hydroxylase mRNA and enzyme activity by cAMP and 12-O-tetradecanoylphorbol-13-acetate (TPA) was studied as a function of different culture conditions in bovine adrenocortical cells. Induction of 21-hydroxylase mRNA and enzyme activity was... |
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Cytophotometric analysis of glycogen, protein and DNA of a glycogen-storing rat hepatoma (N13) cell line.
Virchows Arch.,. B, Cell Pathol. 60(4) , 271-8, (1991) This study examines the behavior of glycogen-storing rat hepatoma (N13) in vitro using cytophotometric techniques. A significant increase in glycogen is observed in these cells after 30 min incubation in a buffered solution containing 0.1 mM glucose, that is ... |
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Production, uptake, and metabolic effects of cyclic AMP in the bivascularly perfused rat liver.
Biochem. Pharmacol. 54(10) , 1115-25, (1997) Production, uptake, and metabolic effects of cyclic AMP (cAMP) were measured in the bivascularly perfused rat liver in anterograde and retrograde perfusion. Glucagon, cAMP, N6,2'-O-dibutyryl cAMP and N6-monobutyryl cAMP were infused into the portal vein (ante... |
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The antilipolytic effect of insulin in human adipocytes requires activation of the phosphodiesterase.
Biochem. Biophys. Res. Commun. 141(3) , 1157-61, (1986) Human fat cells were incubated with two different cAMP analogues, 8-bromocAMP and 6N-monobutyrylcAMP. The former analogue is an excellent substrate for the phosphodiesterase while the latter is resistant to hydrolysis. In the presence of adenosine deaminase, ... |