α-Ketoglutarate dehydrogenase
α-Ketoglutarate dehydrogenase structure
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Common Name | α-Ketoglutarate dehydrogenase | ||
|---|---|---|---|---|
| CAS Number | 9031-02-1 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Initial characterization of the human central proteome.
BMC Syst. Biol. 5 , 17, (2011) On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitously expressed in all human cells. Composition and properties... |
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet. 36 , 40-5, (2004) As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were unique... |
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res. 14 , 2121-7, (2004) The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a r... |
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Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science 325(5942) , 834-40, (2009) Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression. Technological limitations have so far prevented a global analysis of lysine acetylation's cellular roles. We used high-resolution... |
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The DNA sequence and comparative analysis of human chromosome 10.
Nature 429(6990) , 375-81, (2004) The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentromeric region of the short and long arm of the chrom... |
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The full-ORF clone resource of the German cDNA Consortium.
BMC Genomics 8 , 399, (2007) With the completion of the human genome sequence the functional analysis and characterization of the encoded proteins has become the next urging challenge in the post-genome era. The lack of comprehensive ORFeome resources has thus far hampered systematic app... |
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TCA cycle involved enzymes SucA and Kgd, as well as MenD: efficient biocatalysts for asymmetric C-C bond formation.
Org. Lett. 15(3) , 452-5, (2013) Asymmetric mixed carboligation reactions of α-ketoglutarate with different aldehydes were explored with the thiamine diphosphate dependent enzymes SucA from E. coli, Kgd from Mycobacterium tuberculosis, and MenD from E. coli. All three enzymes proved to be ef... |
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Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site.
Biochem. J. 459(2) , 369-81, (2014) The regulation of the 2-oxoglutarate dehydrogenase complex is central to intramitochondrial energy metabolism. In the present study, the active full-length E1 subunit of the human complex has been expressed and shown to be regulated by Ca2+, adenine nucleotid... |
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The DNA sequence of human chromosome 7.
Nature 424(6945) , 157-64, (2003) Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present more t... |
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DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria.
Am. J. Hum. Genet. 91(6) , 1082-7, (2012) Abnormalities in metabolite profiles are valuable indicators of underlying pathologic conditions at the molecular level. However, their interpretation relies on detailed knowledge of the pathways, enzymes, and genes involved. Identification and characterizati... |