(+)-PENTAZOCINE-DEA SCHEDULE IV ITEM
(+)-PENTAZOCINE-DEA SCHEDULE IV ITEM structure
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Common Name | (+)-PENTAZOCINE-DEA SCHEDULE IV ITEM | ||
|---|---|---|---|---|
| CAS Number | 7361-76-4 | Molecular Weight | 285.424 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 403.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C19H27NO | Melting Point | N/A | |
| MSDS | USA | Flash Point | 180.8±27.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Allosteric modulation of sigma-1 receptors elicits anti-seizure activities.
Br. J. Pharmacol. 172 , 4052-65, (2015) Application of orthosteric sigma-1 receptor agonists as anti-seizure drugs has been hindered by questionable efficacy and potential adverse effects. Here, we have investigated the anti-seizure effects of the novel and potent allosteric modulator of sigma-1 re... |
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Involvement of hypothalamic neuropeptide Y in pentazocine induced suppression of food intake in rats.
Neuropeptides 48(3) , 133-41, (2014) The potent orexigenic peptide neuropeptide Y (NPY) has been considered as a possible endogenous ligand for a subpopulation of sigma receptors (SigR). However, their mutual interaction with reference to feeding behavior remains poorly understood. In the presen... |
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Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain.
J. Med. Chem. 57(24) , 10404-23, (2014) The discovery and synthesis of a new series of pyrimidines as potent sigma-1 receptor (σ1R) antagonists, associated with pharmacological antineuropathic pain activity, are the focus of this article. The new compounds were evaluated in vitro in σ-1 and σ-2 rec... |
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Urine Mescaline Screening With a Biochip Array Immunoassay and Quantification by Gas Chromatography-Mass Spectrometry.
Ther. Drug Monit. 37 , 805-11, (2015) Mescaline, the primary psychoactive chemical in peyote cactus, has been consumed for thousands of years in ancient religious ceremonies. The US military wanted to determine if mescaline intake was a problem for personnel readiness. Twenty thousand seventeen u... |
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In vitro and in vivo characterization of two C-11-labeled pet tracers for vesicular acetylcholine transporter.
Mol. Imaging Biol. 16(6) , 773-80, (2014) The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. Herein, two potent and selective (11)C-labeled VAChT inhibitors were evaluated in rodents and nonhuman primates for imaging VAChT in vivo.For ... |
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Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter.
Bioorg. Med. Chem. 23 , 4699-709, (2015) Nine fluorine-containing vesicular acetylcholine transporter (VAChT) inhibitors were synthesized and screened as potential PET tracers for imaging the VAChT. Compound 18a was one of the most promising carbonyl-containing benzovesamicol analogs; the minus enan... |
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Development and validation of an LC-MS/MS method for the simultaneous analysis of 28 specific narcotic adulterants used in dietary supplements.
Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1029-39, (2015) The purpose of this study was to develop a method to analyse the concentration of multiple illegal narcotics present in dietary supplements. To this end, we established and optimised a procedure using LC-MS/MS simultaneously to analyse 28 narcotic compounds i... |
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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.
PLoS ONE 9(11) , e111899, (2014) Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor proteins is re... |
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Sigma-1 receptor stimulation protects retinal ganglion cells from ischemia-like insult through the activation of extracellular-signal-regulated kinases 1/2.
Exp. Eye Res. 128 , 156-69, (2014) Sigma-1 receptor (σ-1) activation and mitogen-activated protein kinases (MAPKs) have been shown to protect retinal ganglion cells (RGCs) from cell death. The purpose of this study was to determine if σ-1 receptor stimulation with pentazocine could promote neu... |
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Fasudil, a Rho‑kinase inhibitor, prevents intima‑media thickening in a partially ligated carotid artery mouse model: Effects of fasudil in flow‑induced vascular remodeling.
Mol. Med. Report. 12 , 7317-25, (2015) Vascular remodeling in response to hemodynamic alterations is a physiological process that requires coordinated signaling between endothelial, inflammatory and vascular smooth muscle cells (VSMCs). Extensive experimental and clinical studies have indicated th... |