1,4,8,11-TETRAAZACYCLOTETRADECANE-5,7-DIONE

1,4,8,11-TETRAAZACYCLOTETRADECANE-5,7-DIONE Structure
1,4,8,11-TETRAAZACYCLOTETRADECANE-5,7-DIONE structure
Common Name 1,4,8,11-TETRAAZACYCLOTETRADECANE-5,7-DIONE
CAS Number 63972-19-0 Molecular Weight 228.29100
Density 1.012 g/cm3 Boiling Point 552.1ºC at 760 mmHg
Molecular Formula C10H20N4O2 Melting Point 172-176ºC(lit.)
MSDS Chinese USA Flash Point 234.8ºC
Symbol GHS05
GHS05
Signal Word Danger

The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia.

J. Nucl. Med. 43(6) , 837-50, (2002)

The cyclam ligand (1,4,8,11-tetraazacyclotetradecane) was condensed with various azomycin-containing synthons to produce chemical compounds that could chelate radioactive metals. It was expected that these radiolabeled markers would become bound selectively t...

Chemistry of constrained dioxocyclam ligands with Co(III): unusual examples of C-H and C-N bond cleavage.

Inorg. Chem. 42(23) , 7602-7, (2003)

The reactions between H(2)dc3 and Co(acac)(3) have been studied in the presence and absence of base. In the presence of base, a complex with an intramolecular Co-C bond, Co(dc3-C-(8))(H(2)O), 1, is formed, presumably through heterolytic C-H bond activation. A...

N-functionalization of poly(ethylene glycol)-linked mono- and bis-dioxocyclams as potential ligands for Gd3+.

J. Org. Chem. 68(22) , 8409-15, (2003)

A number of highly functionalized dioxocyclams with acetic acid side chains on the secondary amine sites and ethylene glycol side chains on 6 and 13-positions (12a, 12b) or a tetra(ethylene glycol) side chain linking the 6 and 13 positions (15) were synthesiz...

Cardiac stimulating effects of macrocyclic polyamines.

Jpn. J. Pharmacol. 32(2) , 394-6, (1982)

Synthesis and properties of cobalt(III) complexes of 4-substituted pyridine-capped dioxocyclams.

Inorg. Chem. 44(25) , 9162-74, (2005)

Cobalt(III) acetate and cyanide complexes of a series of 5,12-dioxocyclams capped across the 1,8-position by 4-substituted pyridines or pyrazine were synthesized and fully characterized. Both the spectroscopic and structural parameters for these complexes wer...

Synthesis and complexation of "back-to-back" capped bis-dioxocyclams.

Inorg. Chem. 44(16) , 5858-65, (2005)

Pyridine-capped 5,12-dioxocyclams were coupled "back-to-back" directly, with one or two intervening phenyl groups, an ethynyl group, or a diazo group via Suzuki, Sonogashira, or reductive coupling of the 4-nitropyridine monocyclam. These bis-dioxocyclams link...