MLS 1547

MLS 1547 Structure
MLS 1547 structure
Common Name MLS 1547
CAS Number 315698-36-3 Molecular Weight 354.833
Density 1.4±0.1 g/cm3 Boiling Point 555.8±50.0 °C at 760 mmHg
Molecular Formula C19H19ClN4O Melting Point N/A
MSDS Chinese USA Flash Point 289.9±30.1 °C
Symbol GHS06
GHS06
Signal Word Danger

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.

Mol. Pharmacol. 86(1) , 96-105, (2014)

A high-throughput screening campaign was conducted to interrogate a 380,000+ small-molecule library for novel D2 dopamine receptor modulators using a calcium mobilization assay. Active agonist compounds from the primary screen were examined for orthogonal D2 ...