Tyrphostin 51
Tyrphostin 51 structure
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Common Name | Tyrphostin 51 | ||
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| CAS Number | 126433-07-6 | Molecular Weight | 268.228 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 788.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C13H8N4O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 430.5±32.9 °C | |
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Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.
J. Med. Chem. 32 , 2344, (1989) A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the substrate site of the EGF receptor kinase domain. These compe... |
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Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.
Science 242(4880) , 933-5, (1988) A systematic series of low molecular weight protein tyrosine kinase inhibitors were synthesized; they had progressively increasing affinity over a 2500-fold range toward the substrate site of epidermal growth factor (EGF) receptor kinase domain. These compoun... |
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Epidermal growth factor receptor inhibition by tyrphostin 51 induces apoptosis in luteinized granulosa cells.
J. Clin. Endocrinol. Metab. 90(1) , 469-73, (2005) Growth factors may be involved in the control of ovarian cell fate and could contribute to regulation of ovarian cell apoptosis. Our objective is to test the hypothesis that, in human luteinized granulosa cells, epidermal growth factor (EGF) works through the... |