Pyroglutamate aminopeptidase I
Pyroglutamate aminopeptidase I structure
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Common Name | Pyroglutamate aminopeptidase I | ||
|---|---|---|---|---|
| CAS Number | 9075-21-2 | Molecular Weight | 284.350 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 449.2±38.0 °C at 760 mmHg | |
| Molecular Formula | C18H20O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 161.1±20.3 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Chronic ethanol intake modifies pyrrolidon carboxypeptidase activity in mouse frontal cortex synaptosomes under resting and K+ -stimulated conditions: role of calcium.
Neurosci. Lett. 439(1) , 75-8, (2008) Pyrrolidon carboxypeptidase (Pcp) is an omega peptidase that removes pyroglutamyl N-terminal residues of peptides such as thyrotrophin-releasing hormone (TRH), which is one of the neuropeptides that has been localized into many areas of the brain and acts as ... |
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Occurrence of the free and Peptide forms of pyroglutamic acid in plasma from the portal blood of rats that had ingested a wheat gluten hydrolysate containing pyroglutamyl peptides.
J. Agric. Food Chem. 54(19) , 6984-8, (2006) In order to determine pyroglutamic acid levels in plasma, we developed a method based on precolumn derivatization of the carboxyl group of pyroglutamic acid with 2-nitrophenylhydrazine. Eight-week-old male SD strain rats were administered 200 mg of an acidic ... |
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Differentiation of Leishmania major is impaired by over-expression of pyroglutamyl peptidase I.
Mol. Biochem. Parasitol. 150(2) , 318-29, (2006) Pyroglutamyl peptidases I (PPI) are cysteine peptidases of the clan CF, family C15, which hydrolyse N-terminal l-pyroglutamyl residues (l-pGlu). The l-pGlu modification is a post-transcriptional modification that confers relative aminopeptidase resistance and... |
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The expression of TRH, its receptors and degrading enzyme is differentially modulated in the rat limbic system during training in the Morris water maze.
Neurochem. Int. 50(2) , 404-17, (2007) TRH administration induces arousal, improves cognition, and modulates glutamatergic and cholinergic transmission in hippocampal neurons. To study the possible involvement of TRH neurons in learning and memory processes, gene expression of TRH, its receptors, ... |
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Structural characterization of a trapped folding intermediate of pyrrolidone carboxyl peptidase from a hyperthermophile.
Biochemistry 51(31) , 6089-96, (2012) The refolding of cysteine-free pyrrolidone carboxyl peptidase (PCP-0SH) from a hyperthermophile is unusually slow. PCP-0SH is trapped in the denatured (D1) state at 4 °C and pH 2.3, which is different from the highly denatured state in the presence of concent... |
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The removal of pyroglutamic acid from monoclonal antibodies without denaturation of the protein chains.
Anal. Biochem. 342(1) , 120-5, (2005) Typically, the removal of pyroglutamate from the protein chains of immunoglobulins with the enzyme pyroglutamate aminopeptidase requires the use of chaotropic and reducing agents, quite often with limited success. This article describes a series of optimizati... |
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Ontogeny of prolyl endopeptidase and pyroglutamyl peptidase I in rat tissues.
Regul. Pept. 139(1-3) , 52-8, (2007) Prolyl endopeptidase and pyroglutamyl peptidase I are enzymes which participate in the degradation of thyrotropin-releasing hormone (TRH), a hormone which is thought to play an important role in the development of organs and tissues. Here, we have characteriz... |
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Activity of soluble aminopeptidase A and dipeptidyl peptidase IV and membrane-bound aminopeptidase B and pyroglutamyl peptidase I in adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis.
Int. J. Pediatr. Otorhinolaryngol. 75 , 1399-1403, (2011) To analyze soluble and membrane-bound peptidase activities in the tonsils and adenoids removed from patients with adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis.A total of 48 tissue samples from patients undergoing adenoidectomy and tonsil... |
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Mutational analysis of the active site of Pseudomonas fluorescens pyrrolidone carboxyl peptidase.
J. Bacteriol. 178(11) , 3308-13, (1996) On the basis of chemical inhibition studies and a multiple alignment of four pyrrolidone carboxyl peptidase (Pcp) amino acid sequences, seven conserved residues of the Pseudomonas fluorescens Pcp, which might be important for enzyme activity, have been modifi... |
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Streptococcus merionis sp. nov., isolated from Mongolian jirds (Meriones unguiculatus).
Int. J. Syst. Evol. Microbiol. 59(Pt 4) , 766-70, (2009) Gram-positive, catalase-negative, chain-forming, coccus-shaped organisms were isolated both from intraperitoneally grown vesicles of the fox tapeworm Echinococcus multilocularis and the oropharynges of laboratory-kept Mongolian jirds (Meriones unguiculatus). ... |