methyl phenyl 8-azabicyclo[3.2.1]octane-2,3-dicarboxylate
![methyl phenyl 8-azabicyclo[3.2.1]octane-2,3-dicarboxylate Structure](https://image.chemsrc.com/caspic/471/61585-22-6.png)
methyl phenyl 8-azabicyclo[3.2.1]octane-2,3-dicarboxylate structure
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Common Name | methyl phenyl 8-azabicyclo[3.2.1]octane-2,3-dicarboxylate | ||
|---|---|---|---|---|
| CAS Number | 61585-22-6 | Molecular Weight | 325.787 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H20ClNO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 2℃ | |
| Symbol |
GHS02, GHS06 |
Signal Word | Danger | |
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Sensitive method for detection of cocaine and associated analytes by liquid chromatography-tandem mass spectrometry in urine.
J. Anal. Toxicol. 33(8) , 447-55, (2009) Cocaine (COC) is a potent CNS stimulant that is metabolized to benzoylecgonine (BE) and further metabolized to minor metabolites such as m-hydroxybenzoylecgonine (m-HOBE). COC is also metabolized to norcocaine (NC). Cocaethylene (CE) is formed when cocaine an... |
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Application of discriminant analysis to differentiate between incorporation of cocaine and its congeners into hair and contamination.
Forensic Sci. Int. 176(1) , 13-8, (2008) The requirement to differentiate between incorporation and external contamination of drugs into hair is undisputed, in particular when dealing with compounds which are administered by sniffing or inhalation (e.g. cocaine). With the aim of making this discrimi... |
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Quantitation of cocaine, benzoylecgonine, cocaethylene, methylecgonine, and norcocaine in human hair by positive ion chemical ionization (PICI) gas chromatography-tandem mass spectrometry.
J. Anal. Toxicol. 24(7) , 489-95, (2000) A total of 30 human head-hair samples were analyzed for cocaine (COC), cocaethylene (CE), benzoylecgonine (BE), methylecgonine (EME), and norcocaine (NCOC) using a sensitive positive ion chemical ionization gas chromatography-tandem mass spectrometry (GC-MS-M... |
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Development and validation of a gas chromatography/ion trap-mass spectrometry method for simultaneous quantification of cocaine and its metabolites benzoylecgonine and norcocaine: application to the study of cocaine metabolism in human primary cultured renal cells.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(30) , 3083-8, (2010) Acute renal failure is a common finding in cocaine abusers. While cocaine metabolism may contribute to its nephrotoxic mechanisms, its pharmacokinetics in kidney cells is hitherto to be clarified. Primary cultures of human proximal tubular cells (HPTCs) provi... |
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Cocaine and its major metabolites in plasma and urine samples from patients in an urban emergency medicine setting.
J. Anal. Toxicol. 24(7) , 478-81, (2000) In this retrospective study, we examined the levels of cocaine and its major metabolites in plasma and urine from 29 randomly selected emergency department patients (19 males and 10 females, aged 19 to 55) whose urine screened positive for benzoylecgonine usi... |
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The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry.
Mol. Pharmacol. 80(6) , 1119-27, (2011) Cocaine toxicity is a widespread problem in the United States, responsible for more than 500,000 emergency department visits a year. There is currently no U.S. Food and Drug Administration-approved pharmacotherapy to directly treat cocaine toxicity. To this e... |
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Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer.
Med. Hypotheses 64(2) , 350-6, (2005) Cocaine is one of the principal drugs of abuse. Although impressive advances have been made, unanswered questions remain concerning mechanism of toxicity and addiction. Discussion of action mode usually centers on receptor binding and enzyme inhibition, with ... |
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Estrogen and progesterone affect cocaine pharmacokinetics in female rats.
Brain Res. Bull. 68(5) , 310-4, (2006) Several studies have reported sex differences in behavioral responses to cocaine whereby females display a greater degree of locomotor activity. Fluctuations in estrogen and progesterone during the estrous cycle have been postulated to underlie these behavior... |
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A rapid, sensitive assay for cocaine and its metabolites in biological fluids using solid-phase extraction and high-performance liquid chromatography.
J. Anal. Toxicol. 24(6) , 438-41, (2000) An improved method for the simultaneous determination of cocaine and its metabolites, benzoylecgonine (BE), norcocaine, and ecgoninemethylester (EME), in rat plasma and urine is described. Following derivatization of EME to p-fluorococaine, chromatography was... |
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Determination of the highest no-effect dose (HNED) and of the elimination pattern for cocaine in horses.
J. Appl. Toxicol. 22(2) , 117-21, (2002) Cocaine is one of the most widespread illegal stimulants utilized by the human population throughout the world. The aim of this study was to establish the highest no-effect dose (HNED) of cocaine on the spontaneous locomotor activity (SLA) of horses in a beha... |