ZL006
ZL006 structure
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Common Name | ZL006 | ||
|---|---|---|---|---|
| CAS Number | 1181226-02-7 | Molecular Weight | 328.147 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 530.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C14H11Cl2NO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 274.6±30.1 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions.
Sci. Rep. 5 , 12157, (2015) ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. Here, we investigate the proposed mechanism of action o... |
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Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics.
Neuropharmacology 97 , 464-75, (2015) Aberrant increases in NMDA receptor (NMDAR) signaling contributes to central nervous system sensitization and chronic pain by activating neuronal nitric oxide synthase (nNOS) and generating nitric oxide (NO). Because the scaffolding protein postsynaptic densi... |
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Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system.
Sci. Rep. 5 , 12651, (2015) The treatment for ischemic stroke is one of the most challenging problems and the therapeutic effect remains unsatisfied due to the poor permeation of drugs across the blood brain barrier (BBB). In this study, HAIYPRH (T7), a peptide that targeted to transfer... |