gldh
gldh structure
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Common Name | gldh | ||
|---|---|---|---|---|
| CAS Number | 9029-12-3 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.
PLoS ONE 10 , e0127785, (2015) The cystine-glutamate antiporter (system xc-) is a Na+-independent amino acid transporter that exchanges extracellular cystine for intracellular glutamate. It is thought to play a critical role in cellular redox processes through regulation of intracellular g... |
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Extensive Charge Reduction and Dissociation of Intact Protein Complexes Following Electron Transfer on a Quadrupole-Ion Mobility-Time-of-Flight MS.
J. Am. Soc. Mass Spectrom. 26 , 1068-76, (2015) Non-dissociative charge reduction, typically considered to be an unwanted side reaction in electron transfer dissociation (ETD) experiments, can be enhanced significantly in order to reduce the charge state of intact protein complexes to as low as 1+ on a com... |
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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
Nature 496(7443) , 101-5, (2013) Cancer cells have metabolic dependencies that distinguish them from their normal counterparts. Among these dependencies is an increased use of the amino acid glutamine to fuel anabolic processes. Indeed, the spectrum of glutamine-dependent tumours and the mec... |
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Synapse formation and maintenance by C1q family proteins: a new class of secreted synapse organizers.
Eur. J. Neurosci. 32(2) , 191-7, (2010) Several C1q family members, especially the Cbln and C1q-like subfamilies, are highly and predominantly expressed in the central nervous system. Cbln1, a member of the Cbln subfamily, plays two unique roles at parallel fiber (PF)-Purkinje cell synapses in the ... |
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Mutations in human GLUD2 glutamate dehydrogenase affecting basal activity and regulation.
J. Neurochem. 109 Suppl 1 , 167-73, (2009) Glutamate dehydrogenase (GDH) in human exists in GLUD1 and GLUD2 gene-encoded isoforms (hGDH1 and hGDH2, respectively), differing in their regulation and tissue expression pattern. Whereas hGDH1 is subject to GTP control, hGDH2 uses for its regulation, a nove... |
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The human GLUD2 glutamate dehydrogenase: localization and functional aspects.
Neurochem. Int. 55(1-3) , 52-63, (2009) In all mammals, glutamate dehydrogenase (GDH), an enzyme central to the metabolism of glutamate, is encoded by a single gene (GLUD1 in humans) which is expressed widely (housekeeping). Humans and other primates also possess a second gene, GLUD2, which encodes... |
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Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol.
Appl. Microbiol. Biotechnol. 85(3) , 731-9, (2010) Phosphoglucose isomerase-deficient (pgi1) strains of Saccharomyces cerevisiae were studied for the production of D-ribose and ribitol from D-glucose via the intermediates of the pentose phosphate pathway. Overexpression of the genes coding for NAD(+)-specific... |
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Expression of human GLUD2 glutamate dehydrogenase in human tissues: functional implications.
Neurochem. Int. 61(4) , 455-62, (2012) Glutamate dehydrogenase (GDH), a mitochondrial enzyme with a key metabolic role, exists in the human in hGDH1 and hGDH2 isoforms encoded by the GLUD1 and GLUD2 genes, respectively. It seems that GLUD1 was retroposed to the X chromosome where it gave rise to G... |
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Identification of disulfide bond formation between MitoNEET and glutamate dehydrogenase 1.
Biochemistry 52(50) , 8969-71, (2013) MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 ... |
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The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.
Neurochem. Int. 61(4) , 470-81, (2012) Mammalian glutamate dehydrogenase (GDH) is a housekeeping mitochondrial enzyme (hGDH1 in the human) that catalyses the reversible inter-conversion of glutamate to α-ketoglutarate and ammonia, thus interconnecting amino acid and carbohydrate metabolism. It dis... |