ALPHA-MANNOSIDASE
ALPHA-MANNOSIDASE structure
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Common Name | ALPHA-MANNOSIDASE | ||
|---|---|---|---|---|
| CAS Number | 9025-42-7 | Molecular Weight | 65.408 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | Zn | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Mucolipidosis type III in an adolescent presenting with atypical facial features and skeletal deformities.
Genet. Couns. 24(1) , 7-12, (2013) Mucolipidosis type III (MLIII) (MIM# 252600) is an uncommon autosomal recessive disorder that results from deficiency of the multimeric enzyme, UDP-N-acetylglucosamine-1-phosphotransferase. The enzymatic defect results in deficiencies of lysosomal degradative... |
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Synthesis of kifunensine thioanalogs and their inhibitory activities against HIV-RT and α-mannosidase.
Carbohydr. Res. 365 , 1-8, (2013) An efficient and practical synthesis of kifunensine thioanalogs 1a-c was reported. The bicyclic azasugars fused thiazolidin-4-one 4a-c as key intermediates were first synthesized in good yields of 74-80% via one-pot tandem Staudinger/aza-Wittig/cyclization by... |
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Seasonal changes in Undifilum colonization and swainsonine content of locoweeds.
J. Chem. Ecol. 38(5) , 486-95, (2012) Locoweeds (Astragalus and Oxytropis) are leguminous plants that are toxic due to a symbiotic association with the endophytic fungus Undifilum oxytropis. The fungus produces the alkaloid swainsonine, an α-mannosidase-inhibitor that causes serious damage to mam... |
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Alpha-mannosidase activity in stallion epididymal fluid and spermatozoa
Theriogenology 78(2) , 252-62, (2012) The expression of α-D-mannosidase activity was fluorometrically and electrophoretically assessed in spermatozoa, epididymal fluid and homogenates of stallion epididymal tissue. Enzyme activity had regional differences; it was higher (P < 0.05) in samples from... |
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Secretion of hydrolytic enzymes by fungal strains, isolated from patients with malignant tumors of head and neck, before, during and after radiotherapy.
Ann. Parasitol. 58(1) , 27-35, (2012) One method of treatment used in cancer therapy is radiotherapy which can injure the oral, pharynx or larynx mucosa and predisposes tissue to the development of fungal infections. The aim of the study paper was the mycological examinations of swabs from the or... |
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Profiling of Endo H-released serum N-glycans using CE-LIF and MALDI-TOF-MS--application to rheumatoid arthritis.
Electrophoresis 32(24) , 3510-5, (2011) High-mannose and hybrid-type N-glycans are present in human serum glycoproteins in low abundance but have recently been described to play an important role in immune responses. It is therefore important to find a strategy to selectively analyze their structur... |
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Characterization of the α- and β-mannosidases of Porphyromonas gingivalis.
J. Bacteriol. 195(23) , 5297-307, (2013) Mannose is an important sugar in the biology of the Gram-negative bacterium Porphyromonas gingivalis. It is a major component of the oligosaccharides attached to the Arg-gingipain cysteine proteases, the repeating units of an acidic lipopolysaccharide (A-LPS)... |
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Jack bean α-mannosidase (Jbα-man): tolerance to alkali, chelating and reducing agents and energetics of catalysis and inhibition.
Int. J. Biol. Macromol. 49(5) , 1066-71, (2011) Investigations of the catalytic and structural transitions of jack bean α-mannosidase (Jbα-man) are described in the present paper. The enzyme was maximally stable at pH 5.0; however, when incubated in the pH range of 11.0-12.0, showed 1.3 times higher activi... |
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Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2
Biochim. Biophys. Acta 1822(7) , 1137-46, (2012) Most lysosomal storage diseases are caused by defects in genes encoding for acidic hydrolases. Deficiency of an enzyme involved in the catabolic pathway of N-linked glycans leads to the accumulation of the respective substrate and consequently to the onset of... |
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Synthesis of anomeric 1,5-anhydrosugars as conformationally locked selective α-mannosidase inhibitors.
Bioorg. Med. Chem. 19(22) , 6720-5, (2011) Anomeric 1,5-anhydrosugar 2 was synthesized from d-glucose derived N-Cbz protected aminodiol 8. The key step involves, acid catalyzed hydrolysis of 1,2-acetonide group in 8 to get hemiacetal that concomitantly undergoes formation of the pyranose ring by attac... |