Calcein-AM
Calcein-AM structure
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Common Name | Calcein-AM | ||
|---|---|---|---|---|
| CAS Number | 148504-34-1 | Molecular Weight | 994.86 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 982.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C46H46N2O23 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 548.1±34.3 °C | |
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Sclerotium rolfsii lectin induces stronger inhibition of proliferation in human breast cancer cells than normal human mammary epithelial cells by induction of cell apoptosis.
PLoS ONE 9(11) , e110107, (2014) Sclerotium rolfsii lectin (SRL) isolated from the phytopathogenic fungus Sclerotium rolfsii has exquisite binding specificity towards O-linked, Thomsen-Freidenreich (Galβ1-3GalNAcα1-Ser/Thr, TF) associated glycans. This study investigated the influence of SRL... |
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Developmental tightening of cerebellar cortical synaptic influx-release coupling.
J. Neurosci. 35(5) , 1858-71, (2015) Tight coupling between Ca(2+) channels and the sensor for vesicular transmitter release at the presynaptic active zone (AZ) is crucial for high-fidelity synaptic transmission. It has been hypothesized that a switch from a loosely coupled to a tightly coupled ... |
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Establishment of lipofection for studying miRNA function in human adipocytes.
PLoS ONE 9(5) , e98023, (2014) miRNA dysregulation has recently been linked to human obesity and its related complications such as type 2 diabetes. In order to study miRNA function in human adipocytes, we aimed for the modulation of mature miRNA concentration in these cells. Adipocytes, ho... |
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Up-regulation of connexin-43 expression in bone marrow mesenchymal stem cells plays a crucial role in adhesion and migration of multiple myeloma cells.
Leuk. Lymphoma 56(1) , 211-8, (2015) Multiple myeloma (MM) cells accumulate mainly in the bone marrow (BM) and are closely related to the BM microenvironment. Connexin-43 (Cx43) is the main connexin present in bone marrow mesenchymal stem cells (BMSCs). We found that normal BMSCs expressed a low... |
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Direct chemosensitivity monitoring ex vivo on undissociated melanoma tumor tissue by impedance spectroscopy.
Cancer Res. 74(22) , 6408-18, (2014) Stage III/IV melanoma remains incurable in most cases due to chemotherapeutic resistance. Thus, predicting and monitoring chemotherapeutic responses in this setting offer great interest. To overcome limitations of existing assays in evaluating the chemosensit... |
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Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling
J. Steroid Biochem. Mol. Biol. 144 Pt B , 334-47, (2014) • Age-dependent action of nonylphenol (NP) on mouse neuronal cells was demonstrated. • Estrogen receptor (ER) antagonists potentiated the NP-induced apoptosis and toxicity. • ER agonists inhibited the NP-evoked effects in mouse hippocampal cells. • The retino... |
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Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.
Free Radic. Res. 48(10) , 1206-17, (2014) Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance, and other obesity related complications. So the hypoxia-s... |
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Cargoing P-gp inhibitors via nanoparticle sensitizes tumor cells against doxorubicin.
Int. J. Pharm. 478(2) , 745-52, (2015) Inhibitors against multidrug resistance (MDR) efflux transporters have failed in most clinical settings due to unfavorable pharmacokinetic interactions with co-administered anti-cancer drug and their inherent toxicities. Nanoparticles (NPs) have shown potenti... |
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Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.
Biochem. Pharmacol. 92(2) , 312-25, (2014) Cannabinoids have been shown to promote the expression of the intercellular adhesion molecule 1 (ICAM-1) on lung cancer cells as part of their anti-invasive and antimetastatic action. Using lung cancer cell lines (A549, H460) and metastatic cells derived from... |
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Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions.
Cytotherapy 16(11) , 1486-500, (2014) Human mesenchymal stromal cells (MSCs) are being used in clinical trials, but the best protocol to prepare the cells for administration to patients remains unclear. We previously demonstrated that MSCs could be pre-activated to express therapeutic factors by ... |