laminin
laminin structure
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Common Name | laminin | ||
|---|---|---|---|---|
| CAS Number | 114956-81-9 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Development of a pluripotent stem cell derived neuronal model to identify chemically induced pathway perturbations in relation to neurotoxicity: effects of CREB pathway inhibition.
Toxicol. Appl. Pharmacol. 280(2) , 378-88, (2014) According to the advocated paradigm shift in toxicology, acquisition of knowledge on the mechanisms underlying the toxicity of chemicals, such as perturbations of biological pathways, is of primary interest. Pluripotent stem cells (PSCs), such as human embryo... |
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Characterization of primary neurospheres generated from mouse ventral rostral hindbrain.
Cell Tissue Res. 336(1) , 11-20, (2009) Serotonergic (5-HT) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. However, the molecular mechanis... |
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Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN.
Sci. Rep. 5 , 12600, (2015) Tumor suppressor PTEN mainly functions at two subcellular locations, the plasma membrane and the nucleus. At the plasma membrane, PTEN dephosphorylates the tumorigenic second messenger PIP3, which drives cell proliferation and migration. In the nucleus, PTEN ... |
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Pcdh11x Negatively Regulates Dendritic Branching.
J. Mol. Neurosci. 56 , 822-8, (2015) Proper formation of neuronal dendritic branching is crucial for correct brain function. The number and distribution of receptive synaptic contacts are defined by the size and shape of dendritic arbors. Our previous research found that protocadherin 11 X-linke... |
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Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma.
Mol. Cancer Ther. 14 , 2560-8, (2015) Pediatric high-grade astrocytomas (pHGA) and diffuse intrinsic pontine gliomas (DIPG) are devastating malignancies for which no effective therapies exist. We investigated the therapeutic potential of PARP1 inhibition in preclinical models of pHGA and DIPG. PA... |
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Generation of rat-induced pluripotent stem cells from a new model of metabolic syndrome.
PLoS ONE 9(8) , e104462, (2014) We recently characterized DahlS.Z-Leprfa/Leprfa (DS/obese) rats, derived from a cross between Dahl salt-sensitive rats and Zucker rats, as a new animal model of metabolic syndrome (MetS). Although the phenotype of DS/obese rats is similar to that of humans wi... |
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Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
Elife 4 , (2015) The field of tissue engineering entered a new era with the development of human pluripotent stem cells (hPSCs), which are capable of unlimited expansion whilst retaining the potential to differentiate into all mature cell populations. However, these cells har... |
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PLGA/alginate composite microspheres for hydrophilic protein delivery.
Mater. Sci. Eng. C. Mater. Biol. Appl. 56 , 251-9, (2015) Poly(lactic-co-glycolic acid) (PLGA) microspheres and PLGA/alginate composite microspheres were prepared by a novel double emulsion and solvent evaporation technique and loaded with bovine serum albumin (BSA) or rabbit anti-laminin antibody protein. The addit... |
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miRNA-204 drives cardiomyocyte proliferation via targeting Jarid2.
Int. J. Cardiol. 201 , 38-48, (2015) In mammals, the heart grows by hypertrophy but not proliferation of cardiomyocytes after birth. The paucity of cardiomyocyte proliferation limits cardiac regeneration in a variety of heart diseases. To explore the efficient strategies that drive cardiomyocyte... |
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Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells.
Methods Mol. Biol. 584 , 355-66, (2010) Directed differentiation of human embryonic stem cells (hESCs) to a functional cell type, including neurons, is the foundation for application of hESCs. We describe here a reproducible, chemically defined protocol that allows directed differentiation of hESCs... |