Thioflavine S
Thioflavine S structure
|
Common Name | Thioflavine S | ||
|---|---|---|---|---|
| CAS Number | 1326-12-1 | Molecular Weight | 318.864 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H19ClN2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.
Bioorg. Med. Chem. 22(19) , 5298-307, (2014) Multitarget compounds are increasingly being pursued for the effective treatment of complex diseases. Herein, we describe the design and synthesis of a novel class of shogaol-huprine hybrids, purported to hit several key targets involved in Alzheimer's diseas... |
|
|
β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.
Biochemistry 53(25) , 4081-3, (2014) Aggregation of α-synuclein has been implicated in Parkinson's disease (PD). While many compounds are known to inhibit α-synuclein aggregation, dissolution of aggregates into their constituent monomers cannot be readily achieved. In this study, using a range o... |
|
|
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.
Nat. Commun. 6 , 6176, (2015) In Alzheimer's disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that microglia constitute a barrier with profound impact on plaque composition and toxicity. Usi... |
|
|
Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice.
Neurobiol. Aging 36 , 1820-33, (2015) Apolipoprotein D (apoD) is expressed in the brain and levels are increased in affected brain regions in Alzheimer's disease (AD). The role that apoD may play in regulating AD pathology has not been addressed. Here, we crossed both apoD-null mice and Thy-1 hum... |
|
|
Adipokine pathways are altered in hippocampus of an experimental mouse model of Alzheimer's disease.
J. Nutr. Health Aging 19(4) , 403-12, (2015) A growing body of evidence suggests that β-amyloid peptides (Aβ) are unlikely to be the only factor involved in Alzheimer's disease (AD) aetiology. In fact, a strong correlation has been established between AD patients and patients with type 2 diabetes and/or... |
|
|
Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease.
J. Alzheimers Dis. 44(3) , 797-808, (2015) Recent genetic studies suggest a central role for innate immunity in Alzheimer's disease (AD) pathogenesis, wherein microglia orchestrate neuroinflammation. Kv1.3, a voltage-gated potassium channel of therapeutic relevance in autoimmunity, is upregulated by a... |
|
|
The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis.
Sci. Transl. Med. 7 , 314ra184, (2015) Apolipoprotein E (ApoE) is an important modifier of Alzheimer's disease (AD) pathogenesis, and its abundance has been linked to the clearance of β-amyloid (Aβ) in the brain. The pathways that control the clearance of ApoE in the brain are incompletely underst... |
|
|
Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain.
Neurobiol. Dis. 74 , 281-94, (2015) Histone acetylation is an epigenetic modification that plays a critical role in chromatin remodelling and transcriptional regulation. There is increasing evidence that epigenetic modifications may become compromised in aging and increase susceptibility to the... |
|
|
FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice.
EJNMMI Res. 5 , 20, (2015) Over the last decade, an increasing number of studies have been published on the use of amyloid-β (Aβ) PET imaging with different (18)F-radiopharmaceuticals for clinical characterization of Alzheimer's disease (AD) in different stages. However, distinct study... |
|
|
The workflow from post-mortem human brain sampling to cell microdissection: a Brain Net Europe study.
J. Neural Transm. Gen. Sect. 122 , 975-91, (2015) Brain banks manage and store fully clinically and pathologically characterised brains. The diversity of techniques used in research projects increases. These biological resource centres are made to adapt brain tissue processing. Furthermore, the development o... |