morin r. g.
morin r. g. structure
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Common Name | morin r. g. | ||
|---|---|---|---|---|
| CAS Number | 654055-01-3 | Molecular Weight | 320.251 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H12O8 | Melting Point | 299-300 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.
Sci. Transl. Med. 6(263) , 263ra161, (2014) Lung cancer is the most common human malignancy and leads to about one-third of all cancer-related deaths. Lung adenocarcinomas harboring KRAS mutations, in contrast to those with EGFR and EML4-ALK mutations, have not been successfully targeted. We describe a... |
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Morin hydrate augments phagocytosis mechanism and inhibits LPS induced autophagic signaling in murine macrophage.
Int. Immunopharmacol. 22(2) , 356-65, (2014) Morin, a natural flavonoid that is the primary bioactive constituent of the family Moraceae, has been found to be associated with many therapeutic properties. In this study, we evaluated the immunomodulatory activities of increasing concentration of morin hyd... |
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Drug screening boosted by hyperpolarized long-lived states in NMR.
ChemMedChem 9(11) , 2509-15, (2014) Transverse and longitudinal relaxation times (T1ρ and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS... |
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Al adjuvants can be tracked in viable cells by lumogallion staining.
J. Immunol. Methods 422 , 87-94, (2015) The mechanism behind the adjuvant effect of aluminum salts is poorly understood notwithstanding that aluminum salts have been used for decades in clinical vaccines. In an aqueous environment and at a nearly neutral pH, the aluminum salts form particulate aggr... |
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Molecular properties and myocardial salvage effects of morin hydrate.
Biochem. Pharmacol. 49 , 537-543, (1995) Morin hydrate is a bioactive pigment found in yellow Brazil wood. Recently, we reported that morin hydrate prolongs the survival of three types of cells from the human circulatory system against oxyradicals generated in vitro. The protection excels that given... |
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Comparative protection against oxyradicals by three flavonoids on cultured endothelial cells.
Biochem. Cell Biol. 75 , 717-720, (1997) Oxygen-derived free radicals are known to injure the endothelium of aorta in diverse disorders. In this study we compared the cytoprotective effects of three flavonoids against oxyradical damage to porcine aortic endothelial cells in vitro. Cultured porcine a... |
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In vitro and in vivo inhibitory actions of morin on rat brain phosphatidylinositolphosphate kinase activity.
Life Sci. 61 , 2035-2047, (1997) Phosphatidylinositol-4,5-bisphosphate occupies a central role in signal transduction and in cellular transformation. Phosphatidylinositol-4,5-bisphosphate is produced by the enzymatic phosphorylation of phosphatidylinositol-4-phosphate by phosphatidylinositol... |
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Antioxidation of human low density lipoprotein by morin hydrate.
Life Sci. 57 , PL51-PL56, (1995) Oxidative modification of low density lipoprotein (LDL) has been suggested to be a risk factor for the development of atherosclerosis. Agents which can protect LDL from oxidation may be useful in preventing atherogenesis. Here, we found that morin hydrate, at... |
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Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
J. Immunol. Methods 103 , 1555-62, (2009) Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990–1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter express... |
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Morin hydrate inhibits azo-initiator induced oxidation of human low density lipoprotein.
Life Sci. 58 , PL17-PL22, (1996) We demonstrated that the flavonoid morin hydrate at 75-100 microM protects against the oxidation of low density lipoprotein (LDL) by free radicals produced by 2,2'-azo-bis(2-amidinopropane) dihydrochloride. Morin hydrate reduces the relative electrophoretic m... |