Lanosterin
Lanosterin structure
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Common Name | Lanosterin | ||
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| CAS Number | 79-63-0 | Molecular Weight | 426.717 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 498.9±44.0 °C at 760 mmHg | |
| Molecular Formula | C30H50O | Melting Point | 137 °C | |
| MSDS | Chinese USA | Flash Point | 221.1±20.7 °C | |
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The mannoprotein TIR3 (CAGL0C03872g) is required for sterol uptake in Candida glabrata.
Biochim. Biophys. Acta 1851(2) , 141-51, (2015) Sterol uptake in the pathogenic fungus, Candida glabrata, occurs via the sterol transporter, CgAus1p. Azole inhibition of sterol biosynthesis can under certain circumstances be reversed by adding exogenously sterol. Here we demonstrate that the CgTIR3 (CAGL0C... |
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Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes.
Food Chem. Toxicol. 53 , 317-24, (2013) Ganodermanondiol, a biologically active compound, was isolated from the Lingzhi mushroom (Ganoderma lucidum). The present study examined the protective effects of ganodermanondiol against tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity. Ganodermanondi... |
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FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.
Nat. Commun. 6 , 8613, (2015) FR171456 is a natural product with cholesterol-lowering properties in animal models, but its molecular target is unknown, which hinders further drug development. Here we show that FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (S... |
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A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast.
PLoS ONE 7(11) , e49004, (2012) Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation. Thus, it is difficult to study the effects of the inhibition of various enzymes on the inter... |
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Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.
J. Biol. Chem. 290 , 28822-33, (2015) Plasmalogen biosynthesis is regulated by modulating fatty acyl-CoA reductase 1 stability in a manner dependent on cellular plasmalogen level. However, physiological significance of the regulation of plasmalogen biosynthesis remains unknown. Here we show that ... |
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Transcriptome analysis reveals in vitro cultured Withania somnifera leaf and root tissues as a promising source for targeted withanolide biosynthesis.
BMC Genomics 16 , 14, (2015) The production of metabolites via in vitro culture is promoted by the availability of fully defined metabolic pathways. Withanolides, the major bioactive phytochemicals of Withania somnifera, have been well studied for their pharmacological activities. Howeve... |
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Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells.
Eur. J. Pharmacol. 765 , 415-28, (2015) Statins exhibit anti-leukemic properties due to suppression of the mevalonate pathway by the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, and subsequent depletion of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate. We inv... |
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Phosphatidylinositol binding of Saccharomyces cerevisiae Pdr16p represents an essential feature of this lipid transfer protein to provide protection against azole antifungals.
Biochim. Biophys. Acta 1842(10) , 1483-90, (2014) Pdr16p is considered a factor of clinical azole resistance in fungal pathogens. The most distinct phenotype of yeast cells lacking Pdr16p is their increased susceptibility to azole and morpholine antifungals. Pdr16p (also known as Sfh3p) of Saccharomyces cere... |
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Determination of steroid hormones in human plasma by GC-triple quadrupole MS.
Steroids 99 , 151-4, (2015) A fast and sensitive GC-MS/MS method is proposed to determine pregnenolone, dehydroepiandrosterone (DHEA), testosterone and dihydrotestosterone from human plasma. Steroids were extracted by liquid/liquid extraction, and derivatized with N-methyl-N-trimethylsi... |
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Synthesis of steryl ferulates with various sterol structures and comparison of their antioxidant activity.
Food Chem. 169 , 92-101, (2014) Steryl ferulates synthesised from commercial sterols as well as commercial oryzanol were used to better understand how structural features affect antioxidant activity in vitro by the ABTS(+) radical decolorization assay, by oxidative stability index (OSI) of ... |