(1S,2S)-1,2-Dihydronaphthalene-1,2-diol
(1S,2S)-1,2-Dihydronaphthalene-1,2-diol structure
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Common Name | (1S,2S)-1,2-Dihydronaphthalene-1,2-diol | ||
|---|---|---|---|---|
| CAS Number | 13011-97-7 | Molecular Weight | 162.18500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H10O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Involvement of aldose reductase in naphthalene cataract.
Invest. Ophthalmol. Vis. Sci. 39(1) , 193-7, (1998) The authors investigated the involvement of the enzyme aldose reductase (AR) in naphthalene cataract by using transgenic mice that overexpress AR.Lenses from nontransgenic mice and from transgenic lines CAR222 and CAR648, with different levels of AR, were cul... |
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Cytotoxicity and cytoprotective activity in naphthalenediols depends on their tendency to form naphthoquinones.
Free Radic. Biol. Med. 39(10) , 1368-77, (2005) We consider the cytotoxicity and the protection against oxidative stress for members of the naphthalenediol family and the known antioxidant epigallocatechin gallate (EGCG). Compounds include the 1,2-naphthalenediol (1,2-ND), 1,4-ND, 2,3-ND, 1,8-ND, and 1,4-d... |
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Formation of bound residues by naphthalene and cis-naphthalene-1,2-dihydrodiol.
Chemosphere 56(9) , 853-60, (2004) The formation of bound residues by naphthalene and its metabolite, cis-naphthalene-1,2-dihydrodiol, in a sediment (1% OC), a silty loam soil (2.9% OC) and a peat (26% OC) was examined. The experiments were carried out under both sterile and nonsterile conditi... |
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Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors.
Exp. Eye Res. 68(5) , 601-8, (1999) The effects of aldose reductase inhibitors on lens protein modifications induced by naphthalene-1,2-dihydrodiol were investigated in vitro to confirm the role of aldose reductase on naphthalene cataract formation. HPLC analysis of naphthalene-1, 2-dihydrodiol... |
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Substrate specificities of hybrid naphthalene and 2,4-dinitrotoluene dioxygenase enzyme systems.
J. Bacteriol. 180(9) , 2337-44, (1998) Bacterial three-component dioxygenase systems consist of reductase and ferredoxin components which transfer electrons from NAD(P)H to a terminal oxygenase. In most cases, the oxygenase consists of two different subunits (alpha and beta). To assess the contrib... |
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Direct micellar systems as a tool to improve the efficiency of aromatic substrate conversion for fine chemicals production.
J. Inorg. Biochem. 79(1-4) , 103-8, (2000) Whole-cell bioconversion of naphthalene to (+)-cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene by Escherichia coli JM109(pPS1778) recombinant strain, carrying naphthalene dioxygenase and regulatory genes cloned from Pseudomonas fluorescens N3, in direct micellar... |
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Aldose reductase catalyzes the oxidation of naphthalene-1, 2-dihydrodiol for the formation of ortho-naphthoquinone.
Drug Metab. Dispos. 27(1) , 60-7, (1999) The oxidation of naphthalene-1,2-dihydrodiol (ND) to o-naphthoquinone (NQ) in the lens is believed to be responsible for the formation of cataracts in naphthalene-fed rats. Studies using either recombinant rat lens (RLAR) or human muscle aldose reductase (HMA... |
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Microbial oxidation of naphthalene to cis-1,2-naphthalene dihydrodiol using naphthalene dioxygenase in biphasic media.
Biotechnol. Prog. 24(3) , 593-8, (2008) The selective oxidation of aryl substrates to chiral cis-1,2-dihydrodiols is an industrially important reaction for the production of intermediates that can be used to produce fine chemicals, pharmaceuticals, and many other bioactive natural products. More sp... |
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Ab initio study on the molecular structure of the naphthalene metabolite, trans-1,2-dihydroxy-1,2-dihydronaphthalene.
Carcinogenesis 5(8) , 1097-100, (1984) The molecular geometries of three conformations of trans-1,2-dihydroxy-1,2-dihydronaphthalene have been refined by an ab initio gradient procedure at the 4-21G level to determine the effect of dihydrodiol conformation on arene structure. The preferred conform... |
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Ab initio study on the molecular structure of trans-1,2-dihydroxy-1,2-dihydro-8-fluoronaphthalene.
Cancer Lett. 33(2) , 205-13, (1986) The molecular geometries of two conformations (diequatorial and diaxial) of trans-1,2-dihydroxy-1,2-dihydro-8-fluoronaphthalene have been refined the ab initio gradient method at the 4-21G level to determine the effect of fluoro substitution on the conformati... |