2-Fluoro-5-(trifluoromethyl)phenyl isocyanate

2-Fluoro-5-(trifluoromethyl)phenyl isocyanate Structure
2-Fluoro-5-(trifluoromethyl)phenyl isocyanate structure
Common Name 2-Fluoro-5-(trifluoromethyl)phenyl isocyanate
CAS Number 69922-27-6 Molecular Weight 205.10900
Density 1.418 g/mL at 25 °C(lit.) Boiling Point 53 °C2.5 mm Hg(lit.)
Molecular Formula C8H3F4NO Melting Point N/A
MSDS Chinese USA Flash Point 159 °F
Symbol GHS07
GHS07
Signal Word Warning

Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases.

Bioorg. Med. Chem. Lett. , 4326, (2006)

A series of isothiazolopyrimidines and isoxazolopyrimidines were synthesized and identified as potent KDR inhibitors. SAR studies led to isothiazolopyrimidine urea analogs that potently inhibit VEGFR tyrosine kinases (KDR enzymatic and cellular IC(50) values ...