Puerarin
Puerarin structure
|
Common Name | Puerarin | ||
|---|---|---|---|---|
| CAS Number | 3681-99-0 | Molecular Weight | 416.38 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 791.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H20O9 | Melting Point | 187-189°C | |
| MSDS | Chinese USA | Flash Point | 281.5±26.4 °C | |
|
The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists.
J. Nat. Prod. 68 , 971-3, (2005) The transgenic Arabidopsis plant system, pER8-GFP, may be used as a powerful tool in searching for natural estrogen-agonists/antagonists. Among selected plant extracts and natural products, the method was able to distinguish active extracts (e.g., Glycine max... |
|
|
UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection.
J. Pharm. Biomed. Anal. 72 , 127-33, (2013) A rapid, sensitive and selective ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method for the simultaneous determination of three active flavonoid glycosides: luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D... |
|
|
Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds.
Bioorg. Med. Chem. Lett. 20 , 4333-6, (2010) Chemical treatment of diabetes mellitus is widely studied and controlling of blood glucose level is the main course of therapy. In type 2 diabetes mellitus, insulin resistance is the major problem. An isoflavone C-glucoside, puerarin (1), is known to enhance ... |
|
|
Polyamidomine dendrimers: an excellent drug carrier for improving the solubility and bioavailability of puerarin.
Pharm. Dev. Technol. 18(5) , 1051-7, (2013) The potential of polyamidoamine (PAMAM) dendrimers as solubility enhancers and oral drug delivery system was well known. Herein, we investigated the possibility of PAMAM dendrimers for promoting the solubility and oral bioavailability of puerarin. In the pres... |
|
|
Identification and assay of 3'-O-methyltaxifolin by UPLC-MS in rat plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 911 , 34-42, (2012) A new metabolite of taxifolin: 3'-O-methyltaxifolin (3'-O-MTAX) in Caco-2 cells and in rat plasma was identified. The chemical structure of 3'-O-MTAX was determined by MS and (1)H NMR. A rapid, sensitive and specific UPLC-MS method to determine 3'-O-MTAX in r... |
|
|
Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-α
J. Steroid Biochem. Mol. Biol. 138 , 421-6, (2013) • Puerarin suppresses proliferation of E2-stimulated ESCs by increasing G1 phase of the cell cycle. • Puerarin downregulates cyclin D1 and cdc25A expression in E2-stimulated ESCs. • Puerarin changes recruitment pattern of nuclear receptor coregulators to estr... |
|
|
Isolation, identification and pharmacokinetic analysis of fructosyl puerarins from enzymatic glycosylation.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 935 , 70-4, (2013) A method of using high-speed counter-current chromatography (HSCCC) was established for preparative isolation and purification of puerarin glycosides from the crude sample after enzymatic glycosylation of puerarin. Four fructosyl puerarins were successfully p... |
|
|
Puerarin injection for unstable angina pectoris.
Cochrane Database Syst. Rev. (3) , CD004196, (2006) Puerarin is extracted from the Chinese herb puerariae lobata. Many users of Chinese herbal medicine believe that puerarin has positive effects in the treatment of coronary heart disease (CHD). In recent years puerarin injection has been widely used to treat C... |
|
|
Lymphatic transport of puerarin occurs after oral administration of different lipid-based formulations to unconscious lymph duct-cannulated rats.
Pharm. Dev. Technol. 19(6) , 743-7, (2014) This study investigated the potential of targeted intestinal lymphatic transport of puerarin via a lipid formulation approach. Three formulations of PEG nanoemulsion, nanosuspension and an oil suspension containing puerarin were examined with the lymph-cannul... |
|
|
Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury.
J. Surg. Res. 186(1) , 328-37, (2014) A wealth of evidence has suggested that oxidative stress is involved in the secondary brain injury after traumatic brain injury (TBI). Recently, numerous in vivo and in vitro studies were reported that puerarin could inhibit oxidative stress through the activ... |