The Journal of Steroid Biochemistry and Molecular Biology 2013-11-01

Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-α

Mei Ji, Yuhuan Liu, Shengsheng Yang, Dongxia Zhai, Danying Zhang, Lingling Bai, Zhenzhi Wang, Jin Yu, Chaoqin Yu, Zailong Cai

Index: J. Steroid Biochem. Mol. Biol. 138 , 421-6, (2013)

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Abstract

• Puerarin suppresses proliferation of E2-stimulated ESCs by increasing G1 phase of the cell cycle. • Puerarin downregulates cyclin D1 and cdc25A expression in E2-stimulated ESCs. • Puerarin changes recruitment pattern of nuclear receptor coregulators to estrogen receptor-α in E2-stimulated ESCs.