2,3,7,8-Tetrachlorodibenzo-p-dioxin
2,3,7,8-Tetrachlorodibenzo-p-dioxin structure
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Common Name | 2,3,7,8-Tetrachlorodibenzo-p-dioxin | ||
|---|---|---|---|---|
| CAS Number | 1746-01-6 | Molecular Weight | 321.971 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 417.9±45.0 °C at 760 mmHg | |
| Molecular Formula | C12H4Cl4O2 | Melting Point | 284-287°C | |
| MSDS | USA | Flash Point | 164.2±28.8 °C | |
| Symbol |
GHS02, GHS07, GHS08, GHS09 |
Signal Word | Danger | |
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Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR).
Toxicol. Appl. Pharmacol. 278(1) , 65-71, (2014) The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented. Fibroblast growth factor (Fgf) 21 plays critical roles in metabolic adaptation to fasting b... |
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A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.
Arch. Toxicol. 89 , 2413-27, (2015) Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through seve... |
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Interactive effects of n-TiO2 and 2,3,7,8-TCDD on the marine bivalve Mytilus galloprovincialis.
Aquat. Toxicol. 153 , 53-65, (2014) Despite the growing concern over the potential biological impact of nanoparticles (NPs) in the aquatic environment, little is known about their interactions with other pollutants. The bivalve Mytilus sp, largely utilized as a sentinel for marine contamination... |
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Morphine glucuronidation increases its analgesic effect in guinea pigs.
Life Sci. 109(2) , 104-10, (2014) Morphine is extensively metabolized to neurotoxic morphine-3-glucuronide (M3G) and opioid agonist morphine-6-glucuronide (M6G). Due to these different roles, interindividual variability and co-administration of drugs that interfere with metabolism may affect ... |
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Cross-omics gene and protein expression profiling in juvenile female mice highlights disruption of calcium and zinc signalling in the brain following dietary exposure to CB-153, BDE-47, HBCD or TCDD.
Toxicology 321 , 1-12, (2014) The present study assessed if eating a diet of fish, spiked with persistent organic pollutants (POPs), affects gene and protein expression in the maturing mouse brain. Juvenile female Balb/c mice (22 days of age) were exposed for 28 days to fish-based diets s... |
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Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands.
Mol. Pharmacol. 85(2) , 279-89, (2014) Omeprazole (OME) induces the expression of genes encoding drug-metabolizing enzymes, such as CYP1A1, via activation of the aryl hydrocarbon receptor (AhR) both in vivo and in vitro. However, the precise mechanism of OME-mediated AhR activation is still under ... |
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Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish.
Aquat. Toxicol. 154 , 19-26, (2014) The cardiovascular system is one of the most characteristic and important targets for developmental toxicity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in fish larvae. However, knowledge of the mechanism of TCDD-induced edema after heterodimerization of ar... |
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Mixed Halogenated Dioxins/Furans (PXDD/Fs) and Biphenyls (PXBs) in Food: Occurrence and Toxic Equivalent Exposure using Specific Relative Potencies
Environ. Int. 73 , 104-10, (2014) The occurrence of nineteen mixed halogenated (bromo-chloro) dibenzo-p-dioxins, dibenzofurans (PXDD/Fs) and biphenyls (PXBs) in a range of foods (n>100) was investigated. The analytical methodology used dual activated carbon column fractionation with high reso... |
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Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik.
Environ. Int. 59 , 282-9, (2013) Recent evidence suggests that exposure to persistent organic pollutants (POPs) increases the risk of hypertension in environmentally exposed populations. High POP levels have been detected in Arctic populations and the exposure is related to high consumption ... |
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Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population.
Environ. Int. 59 , 456-61, (2013) Dioxin exposure has experimentally been associated with changes in DNA methylation, an epigenetic change that is associated with disease. The present study aims to investigate if serum levels of dioxin and other persistent environmental pollutants are related... |