1,3-DINITROGLYCERIN
1,3-DINITROGLYCERIN structure
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Common Name | 1,3-DINITROGLYCERIN | ||
|---|---|---|---|---|
| CAS Number | 623-87-0 | Molecular Weight | 182.08900 | |
| Density | 1.594 g/cm3 | Boiling Point | 170.2ºC at 760 mmHg | |
| Molecular Formula | C3H6N2O7 | Melting Point | 26°C | |
| MSDS | N/A | Flash Point | 56.8ºC | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Biotransformation of glyceryl trinitrate by rat brain homogenate.
Can. J. Physiol. Pharmacol. 70(6) , 935-7, (1992) Incubation of glyceryl trinitrate (GTN) with 5% (w/v) rat brain homogenate (RBH) resulted in biotransformation of the organic nitrate vasodilator drug to a mixture of glyceryl-1,2-dinitrate (1,2-GDN) and glyceryl-1,3-dinitrate (1,3-GDN). Heating of the RBH at... |
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Effect of temperature on glyceryl trinitrate induced relaxation of rabbit aorta.
Can. J. Physiol. Pharmacol. 71(8) , 629-32, (1993) It has previously been shown that the vasodilatory response to glyceryl trinitrate (GTN) was decreased during hypothermic cardiopulmonary bypass. The purpose of these experiments was to determine the effect of temperature on GTN-induced relaxation and on GTN ... |
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Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report.
J. Pharmacokinet. Biopharm. 21(2) , 163-73, (1993) Studies were carried out in conscious dogs to determine the effects of 1,2-glyceryl dinitrate (1,2-GDN) and 1,3-glyceryl dinitrate (1,3-GDN) on nitroglycerin (GTN) pharmacokinetics and pharmacodynamics. In the first set of experiments, steady state plasma lev... |
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Vascular and anti-platelet actions of 1,2- and 1,3-glyceryl dinitrate.
Br. J. Pharmacol. 110(3) , 937-42, (1993) 1. The aim of this study was to investigate whether two metabolites of glyceryl trinitrate (GTN), 1,2 and 1,3-glyceryl dinitrate (1,2-GDN and 1,3-GDN) could account for the pharmacological effects of GTN. To this end the formation of nitric oxide (NO) from 1,... |
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Dose proportionality of transdermal nitroglycerin.
Pharm. Res. 9(10) , 1284-9, (1992) The FDA Cooperative Efficacy Study of transdermal nitroglycerin utilized a combination of marketed products over a wide dose range. Unfortunately, plasma nitroglycerin concentrations were not determined. The current study was conducted to assess plasma nitrat... |
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Pharmacokinetics of nitroglycerin and its metabolites after administration of sustained-release tablets.
Biopharm. Drug Dispos. 13(2) , 141-52, (1992) Nitroglycerin was administered to eight healthy volunteers in the form of sublingual tablets, oral sustained-release tablets, and an oral solution. Blood samples were collected for measurement of nitroglycerin and its two isomeric glyceryl dinitrate metabolit... |
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Impaired nitroglycerin biotransformation in patients with chronic heart failure.
Clin. Physiol. Funct. Imaging 28(4) , 229-34, (2008) Patients with chronic heart failure (CHF) often require higher doses of nitroglycerin (glyceryl trinitrate, GTN) than patients with normal cardiac function to achieve a given haemodynamic goal. Two pathways leading to biotransformation of GTN have been charac... |
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Bioavailability and pharmacokinetic profile of glyceryl trinitrate and of glyceryl dinitrates during application of a new glyceryl trinitrate transdermal patch.
Arzneimittelforschung 50(9) , 779-85, (2000) The pharmacokinetics and bioavailability of glyceryl trinitrate (GTN, CAS 55-63-0) and of its main metabolites, i.e. 1,2-glyceryl dinitrate (1,2-GDN, CAS 621-65-8) and 1,3-glyceryl dinitrate (1,3-GDN, CAS 623-87-0), were compared during a single 24-h applicat... |
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Variable glyceryl dinitrate formation as a function of glutathione S-transferase.
Biol. Pharm. Bull. 19(8) , 1093-6, (1996) Nitroglycerin (GTN) has been used as the drug of choice in the treatment of angina pectoris. It has been shown that some glutathione S-transferases (GSTs) catalyze the metabolic conversion from GTN to glyceryl dinitrates (GDNs). In this study, we examined the... |
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Plasma levels of glyceryl trinitrate and dinitrates during application of three strengths of a new glyceryl trinitrate transdermal patch.
Arzneimittelforschung 50(9) , 786-94, (2000) The pharmacokinetic characteristics and the bioavailability of glyceryl trinitrate (GTN, CAS 55-63-0) and of its main metabolities 1,2-glyceryl dinitrate (1,2-GDN, CAS 621-65-8) and 1,3-glyceryl dinitrate (1,3-GDN, CAS 623-87-0) during a single 24-h applicati... |