carbamazepine-10,11-epoxide
carbamazepine-10,11-epoxide structure
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Common Name | carbamazepine-10,11-epoxide | ||
|---|---|---|---|---|
| CAS Number | 36507-30-9 | Molecular Weight | 252.26800 | |
| Density | 1.377g/cm3 | Boiling Point | 390.2ºC at 760mmHg | |
| Molecular Formula | C15H12N2O2 | Melting Point | 204-206ºC | |
| MSDS | Chinese USA | Flash Point | 189.8ºC | |
| Symbol |
GHS09 |
Signal Word | Danger | |
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Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects.
Clin. Ther. 36(11) , 1638-49, (2014) Vilazodone is a serotonin reuptake inhibitor and 5-HT1A partial agonist approved for the treatment of major depressive disorder in adults. Vilazodone seems to be metabolized primarily by the cytochrome P-450 (CYP) 3A4 isozyme and non-CYP-mediated pathways; co... |
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Evaluation of the potential for pharmacokinetic drug-drug interaction between armodafinil and carbamazepine in healthy adults.
Clin. Ther. 37(2) , 325-37, (2015) Polypharmacy is common in psychiatry practice and can lead to an increased risk of drug interactions. Armodafinil, a wakefulness-promoting agent, has been studied as adjunctive therapy for the treatment of major depressive episodes associated with bipolar I d... |
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Successful treatment of carbamazepine poisoning with hemodialysis: a case report and review of the literature.
Hemodial. Int. 15(3) , 407-11, (2011) A 48-year-old man was brought to the emergency room after ingesting an unknown amount of carbamazepine. He was unconscious and not responding to the noxious stimuli. He was intubated and was placed on mechanical ventilation because of respiratory insufficienc... |
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Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication.
Pharmacol. Rep. 63(1) , 86-94, (2011) Carbamazepine is a widely used anticonvulsive agent. Its metabolic pathway leads not only to the major active metabolite, carbamazepine-10,11-epoxide, but also to minor terminal metabolites such as iminostilbene and acridine. Carbamazepine is usually well-tol... |
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Chemometric resolution of fully overlapped CE peaks: quantitation of carbamazepine in human serum in the presence of several interferences.
Electrophoresis 29(22) , 4527-37, (2008) Drug monitoring in serum samples was performed using second-order data generated by CE-DAD, processed with a suitable chemometric strategy. Carbamazepine could be accurately quantitated in the presence of its main metabolite (carbamazepine epoxide), other the... |
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Carbamazepine is an inhibitor of histone deacetylases.
Life Sci. 76(26) , 3107-15, (2005) Carbamazepine (CBZ) is a common antiepileptic drug (AED) that acts through multiple mechanisms including blockade and potentiation of cation channels and modulation of neurotransmitter levels. Whether it affects any component of the gene transcription machine... |
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Effect of berberine on the pharmacokinetics of substrates of CYP3A and P-gp.
Phytother Res. 23(11) , 1553-8, (2009) The in vivo effects of berberine (BBR), the widely used bioactive herbal ingredient from many traditional Chinese medicinal herbs, on the pharmacokinetics of carbamazepine (CBZ, a substrate of CYP3A) and its metabolite carbamazepine 10,11-epoxide (ECBZ), digo... |
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Instrumental planar chromatographic method for determination of carbamazepine in human serum.
J. Sep. Sci. 32(9) , 1454-8, (2009) An instrumental planar chromatographic (HPTLC) method for quantification of carbamazepine in human serum was developed using liquid-liquid extraction with dichloromethane, fluorescence activation with perchloric acid 60%/ethanol/water (1:1:1, v/v) and fluores... |
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Estimation of carbamazepine and carbamazepine-10,11-epoxide concentrations in plasma using mathematical equations generated with two carbamazepine immunoassays.
Am. J. Clin. Pathol. 133(5) , 728-36, (2010) Carbamazepine is metabolized to an active metabolite known as carbamazepine-10,11-epoxide, or simply the "epoxide" metabolite. The presence of this metabolite can have clinically significant implications in therapeutic drug monitoring of carbamazepine, but ac... |
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Effect of probenecid on the pharmacokinetics of carbamazepine in healthy subjects.
Eur. J. Clin. Pharmacol. 61(4) , 275-80, (2005) Carbamazepine (CBZ) undergoes biotransformation by CYP3A4 and CYP2C8, and glucuronide conjugation. There has been no clear demonstration to reveal the role of glucuronidation in the disposition of CBZ. We evaluated the effect of probenecid, a UDP-glucuronosyl... |