8-CPT-Cyclic AMP sodium
8-CPT-Cyclic AMP sodium structure
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Common Name | 8-CPT-Cyclic AMP sodium | ||
|---|---|---|---|---|
| CAS Number | 93882-12-3 | Molecular Weight | 493.79 | |
| Density | N/A | Boiling Point | 799.2ºC at 760 mmHg | |
| Molecular Formula | C16H14ClN5NaO6PS | Melting Point | N/A | |
| MSDS | USA | Flash Point | 437.1ºC | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation.
Endocrinology 152 , 1829-38, (2011) We have reported that the nuclear factor-κB (NF-κB) induces chronic inflammation in the adipose tissue of p65 transgenic (Tg) mice, in which the NF-κB subunit p65 (RelA) is overexpressed from the adipocyte protein 2 (aP2) gene promoter. Tg mice suffer a mild ... |
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p62/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells.
Cell Death Differ. 21(12) , 1852-61, (2014) The p62/SQSTM1 adapter protein has an important role in the regulation of several key signaling pathways and helps transport ubiquitinated proteins to the autophagosomes and proteasome for degradation. Here, we investigate the regulation and roles of p62/SQST... |
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Visualization of cyclic AMP-regulated presynaptic activity at cerebellar granule cells.
Neuron 20 , 773-781, (1998) Adenylyl cyclase (AC) modulation of vesicular cycling was visualized at cultured cerebellar granule cell synapses using the sequential uptake of antibodies directed against the intraluminal domain of synaptotagmin I. Vesicle recycling due to spontaneous trans... |
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8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA).
Biochem. Pharmacol. 44 , 2303-2306, (1992) 8-(4-Chlorophenyl)thio-cyclic AMP (8-CPT-cAMP), extensively used as selective activator of cyclic AMP-dependent protein kinase, has been found to be a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA). Indeed, 8-CPT-cAMP (IC50 = 0.9 micro... |
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RhoA inactivation prevents photoreceptor axon retraction in an in vitro model of acute retinal detachment.
Invest. Ophthalmol. Vis. Sci. 52 , 579-87, (2011) An early injury response to retinal detachment is disruption of synaptic connectivity between photoreceptors and second-order neurons. Most dramatic is the retraction of rod cell axons and their terminals away from the outer synaptic layer and toward their ce... |
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Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A.
J. Biol. Chem. 273 , 11012-11016, (1998) Formylated peptides (e.g. n-formyl-Met-Leu-Phe (fMLP)) and platelet-activating factor (PAF) mediate chemotactic and cytotoxic responses in leukocytes through receptors coupled to G proteins that activate phospholipase C (PLC). In RBL-2H3 cells, fMLP utilizes ... |
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Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA).
Cell Physiol. Biochem. 21 , 274-81, (2009) There are two major genes encoding the catalytic subunits of protein kinase A, Calpha and Cbeta. The functional significance of these isoforms is enigmatic. Lymphoid cells of the immune system express both Calpha and Cbeta. In this study we tested the role of... |
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Induction of cell cycle arrest at G1 and S phases and cAMP-dependent differentiation in C6 glioma by low concentration of cycloheximide.
BMC Cancer 10 , 684, (2010) Differentiation therapy has been shown effective in treatment of several types of cancer cells and may prove to be effective in treatment of glioblastoma multiforme, the most common and most aggressive primary brain tumor. Although extensively used as a reage... |
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Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers.
Am. J. Physiol. 275 , C1465-C1472, (1998) Although the skeletal muscle sodium channel is a good substrate for cAMP-dependent protein kinase (PKA), no functional consequence was observed for this channel expressed in heterologous systems. Therefore, we investigated the effect of 8-(4-chlorophenylthio)... |