1-chloro-2-methylpropene
1-chloro-2-methylpropene structure
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Common Name | 1-chloro-2-methylpropene | ||
|---|---|---|---|---|
| CAS Number | 513-37-1 | Molecular Weight | 90.55140 | |
| Density | 0.911g/cm3 | Boiling Point | 68.1ºC at 760mmHg | |
| Molecular Formula | C4H7Cl | Melting Point | -96°C (estimate) | |
| MSDS | USA | Flash Point | 30 °F | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Comparative metabolism and disposition of 1-chloro- and 3-chloro-2-methylpropene in rats and mice.
Drug Metab. Dispos. 15(1) , 91-6, (1987) A recent 2-year carcinogenicity study found that gavage administration of 3-chloro-2-methylpropene (CMP), containing 5% 1-chloro-2-methylpropene (dimethylvinyl chloride, DMVC), caused forestomach neoplasms in rats and mice. Similar chronic studies revealed th... |
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Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic - example: 1-methylcyclopropene and its impurities (1-chloro-2-methylpropene and 3-chloro-2-methylpropene).
Food Chem. Toxicol. 48 Suppl 1 , S81-8, (2010) The chlorinated impurities of 1-methylcyclopropene possess weak mutagenicity and are carcinogenic in rodent bioassays. Dose-response modelling of the data for 1-chloro-2-methylpropene gave a BMDL10 for nasal carcinomas in male rats of 11 mg/kg-bw/day (after c... |
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Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program.
Environ. Mol. Mutagen. 23(1) , 51-63, (1994) Fifty chemicals were tested for mutagenic activity in post-meiotic and meiotic germ cells of male Drosophila melanogaster using the sex-linked recessive lethal (SLRL) assay. As in the previous studies in this series, feeding was chosen as the first route of a... |
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1-Chloro-2-methylpropene.
IARC Monogr. Eval. Carcinog. Risks Hum. 63 , 315-24, (1995)
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Dimethylvinyl chloride.
Rep. Carcinog. 12 , 175-6, (2011)
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Dimethylvinyl chloride.
Rep. Carcinog. 11 , III110, (2004)
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Dimethylvinyl chloride.
Rep. Carcinog. 10 , 109-10, (2002)
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Oral administration of dimethylvinyl chloride increases frequency of forestomach papillomas in Tg.AC mice.
Mol. Carcinog. 29(4) , 229-35, (2000) This work was initiated to determine the potential for the Tg.AC mouse model to identify chemical carcinogens by an oral route of administration. Tg.AC v-Ha-ras transgenic mice were exposed to dimethyvinyl chloride (DMVC; 1-chloro-2-methylpropene), a structur... |
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Metabolism of 1-chloro-2-methylpropene. Evidence for reactive chloroaldehyde intermediates.
Drug Metab. Dispos. 16(3) , 449-54, (1988) Recent metabolism and disposition studies of 1-chloro-2-methylpropene (dimethylvinyl chloride) revealed cysteine and N-acetylcysteine conjugates of 3-chloro-2-methylpropenoic acid as the major metabolites. In the present studies we have investigated various s... |
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Transfer reactions involving boron. XVII. On the kinetics of the alpha-transfer reaction. Pasto DJ, et al.
J. Am. Chem. Soc. 90(22) , 6259-6260, (1968)
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