Liver Cell Growth Factor acetate salt

Liver Cell Growth Factor acetate salt Structure
Liver Cell Growth Factor acetate salt structure
Common Name Liver Cell Growth Factor acetate salt
CAS Number 72957-37-0 Molecular Weight 400.430
Density 1.324 g/cmH3 Boiling Point 831ºC at 760 mmHg
Molecular Formula C16H28N6O6 Melting Point N/A
MSDS Chinese USA Flash Point 456.4ºC

Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species.

Endocrinology 156(4) , 1540-51, (2015)

Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the intracellular conc...

Expression analysis of stemness genes in a rat thyroid cell line FRTL5.

Exp. Clin. Endocrinol. Diabetes 123(1) , 48-54, (2015)

Detection and analysis of a small subpopulation of cells such as stem cells or cancer stem cells are recognized to be a key technique in a recent regeneration and cancer science. However, in the thyroid, no marker that identifies stem cells has been establish...

The effect of topical tripeptide-copper complex on healing of ischemic open wounds.

Vet. Surg. 32(6) , 515-23, (2003)

To evaluate the effects of topical glycyl-L-histidyl-L-lysine tripeptide-copper complex (TCC; Iamin 2% Gel; Procyte Corporation, Redmond, WA) on healing in ischemic open wounds.Experimental study.Twenty-four adult male Sprague-Dawley rats.Rats were divided in...

Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations.

J. Pharm. Biomed. Anal. 47(3) , 596-602, (2008)

Acrolein (ACR) is a well-known carbonyl toxin produced by lipid peroxidation of polyunsaturated fatty acids, which is involved in several life-threatening pathologies such as Alzheimer disease, arteriosclerosis, diabetes, and nephropathy. The aim of this work...

Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts.

Arch. Facial Plast. Surg. 7(1) , 27-31, (2005)

To evaluate the effects of copper tripeptide (GHK-Cu) on the growth and autocrine production of basic fibroblast growth factor, transforming growth factor beta1, and vascular endothelial growth factor by normal and irradiated fibroblasts in a serum-free in vi...

Copper.Lys-Gly-His-Lys mediated cleavage of tRNA(Phe): studies of reaction mechanism and cleavage specificity.

J. Inorg. Biochem. 103 , 871-875, (2009)

The reactivity of [Cu2+.Lys-Gly-His-Lys-NH2]2+ and [Cu2+.Lys-Gly-His-Lys]+ toward tRNA(Phe) has been evaluated. The amidated and carboxylate forms of the copper peptides display complex binding behavior with strong and weak sites evident (K(D1)(app) approxima...

A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices.

Life Sci. 80(4) , 275-84, (2007)

Chronically elevated blood glucose levels result in reduced leukocyte function and cell malnutrition, which contribute to a high rate of wound infection and associated healing problems in diabetic patients. In the present study, the role of biotinylated GHK p...

Formation equilibria of nickel complexes with glycyl-histidyl-lysine and two synthetic analogues.

J. Inorg. Biochem. 98(1) , 153-60, (2004)

Complex-formation equilibria between the Ni(II) ion and the natural tripeptide glycyl-L-histidyl-L-lysine have been investigated. Two synthetic analogues, where the histidine residue has been substituted with L-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-c...

The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.

Oxid. Med. Cell. Longev. 2012 , 324832, (2012)

Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to overproduction of proinflammatory cytokines are considered leading causative factors in development of age-associated neurodegenerative conditions. Recently, a new mechanism of aging...

Effects of topical copper tripeptide complex on wound healing in an irradiated rat model.

Otolaryngol. Head Neck Surg. 149(3) , 384-9, (2013)

To evaluate clinical and immunohistopathological effects of topical glycyl-histidyl-lysine-copper (GHK-Cu) on in vivo irradiated rat wounds.Animal model.Academic institution.After dorsal irradiation and a 28-day recovery period, 2 × 8 cm cranially based dorsa...