isoxanthopterin
isoxanthopterin structure
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Common Name | isoxanthopterin | ||
|---|---|---|---|---|
| CAS Number | 529-69-1 | Molecular Weight | 179.13600 | |
| Density | 2.17g/cm3 | Boiling Point | 686.5ºC at 760mmHg | |
| Molecular Formula | C6H5N5O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 369ºC | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Normalization of urinary pteridines by urine specific gravity for early cancer detection.
Clin. Chim. Acta 435 , 42-7, (2014) Urinary biomarkers, such as pteridines, require normalization with respect to an individual's hydration status and time since last urination. Conventional creatinine-based corrections are affected by a multitude of patient factors whereas urine specific gravi... |
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Direct radical scavenging activity of benzbromarone provides beneficial antioxidant properties for hyperuricemia treatment.
Biol. Pharm. Bull. 38(3) , 487-92, (2015) Uric acid exerts an important antioxidant effect against external oxidative stress under physiological conditions. However, uric acid itself can increase oxidative stress via reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation in ad... |
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Purification and partial characterization of xanthine oxidase from human milk.
Biochim. Biophys. Acta 1117(1) , 25-32, (1992) Xanthine oxidase was purified from human milk in yields comparable with those obtained from bovine milk. The freshly purified enzyme appeared homogeneous in gel permeation FPLC and SDS-PAGE, consistent with its being a homodimer with total M(r) 290,000 +/- 60... |
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Pterin detection using surface-enhanced Raman spectroscopy incorporating a straightforward silver colloid-based synthesis technique.
J. Biomed. Opt. 16(7) , 077007, (2011) Optical techniques toward the realization of sensitive and selective biosensing platforms have received considerable attention in recent times. Techniques based on interferometry, surface plasmon resonance, and waveguides have all proved popular, while spectr... |
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Inhibition of GTP cyclohydrolase I by pterins.
Biochim. Biophys. Acta 965(1) , 9-15, (1988) Pterins inhibit rat liver GTP cyclohydrolase I activity noncompetitively. Reduced pterins, such as 7,8-dihydro-D-neopterin, (6R,S)-5,6,7,8-tetrahydro-D-neopterin, 7,8-dihydro-L-biopterin, (6R)-5,6,7,8-tetrahydro-L-biopterin, L-sepiapterin, and DL-6-methyl-5,6... |
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Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography.
J. Chromatogr. B, Biomed. Appl. 681(2) , 395-400, (1996) An assay for human plasma xanthine oxidase activity was developed with pterin as the substrate and the separation of product (isoxanthopterin) by high-performance liquid chromatography with a fluorescence detector. The reaction mixture consists of 60 microlit... |
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Highly sensitive assay for xanthine oxidase activity by high-performance liquid chromatography with fluorescence detection.
J. Chromatogr. A. 424(2) , 392-7, (1988)
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Improvement of base selectivity and binding affinity by controlling hydrogen bonding motifs between nucleobases and isoxanthopterin: application to the detection of T/C mutation.
Bioorg. Med. Chem. Lett. 17(13) , 3682-5, (2007) At an abasic site in an oligo-DNA duplex, isoxanthopterin (IX)(dagger) can bind to thymine (T) and cytosine (C) with strong affinity compared to adenine and guanine, but the base selectivity for T against C is moderate. In order to improve both binding affini... |
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Vibrational spectroscopic (FT-IR and FT-Raman) studies, natural bond orbital analysis and molecular electrostatic potential surface of Isoxanthopterin.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 114 , 101-13, (2013) The FTIR and FT-Raman spectra of Isoxanthopterin have been recorded in the region 4000-450 and 4000-100 cm(-1), respectively. The optimized geometry, frequency and intensity of the vibrational bands of Isoxanthopterin were obtained by the density functional t... |