2'-Deoxycytidine-5'-monophosphoric acid
2'-Deoxycytidine-5'-monophosphoric acid structure
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Common Name | 2'-Deoxycytidine-5'-monophosphoric acid | ||
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| CAS Number | 1032-65-1 | Molecular Weight | 307.197 | |
| Density | 2.0±0.1 g/cm3 | Boiling Point | 633.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C9H14N3O7P | Melting Point | 169-172 °C (dec.) | |
| MSDS | USA | Flash Point | 337.1±34.3 °C | |
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Development of an electrochemical surface-enhanced Raman spectroscopy (EC-SERS) aptasensor for direct detection of DNA hybridization.
Phys. Chem. Chem. Phys. 17 , 21356-63, (2015) Rapid detection of disease biomarkers at the patient point-of-care is essential to timely and effective treatment. The research described herein focuses on the development of an electrochemical surface-enhanced Raman spectroscopy (EC-SERS) DNA aptasensor capa... |
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Metal free columns for determination of deoxynucleotide monophosphate by liquid chromatography/mass spectrometry and application to oligonucleotide.
J. Chromatogr. A. 1406 , 210-4, (2015) We have developed a highly sensitive method for the analysis of deoxynucleotide monophosphates (dNMPs), which involves the use of liquid chromatography/mass spectrometry (LC/MS) and a new metal-free column. The new column solves the problem that the phosphate... |
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The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Antimicrob. Agents Chemother. 52 , 458-64, (2008) beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) is a potent inhibitor of hepatitis C virus (HCV) RNA replication in an HCV replicon assay. The 5'-triphosphate of PSI-6130 is a competitive inhibitor of the HCV RNA-dependent RNA polymerase (RdRp) and a... |
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Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
Antimicrob. Agents Chemother. 51 , 503-9, (2007) Beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) is a potent specific inhibitor of hepatitis C virus (HCV) RNA synthesis in Huh-7 replicon cells. To inhibit the HCV NS5B RNA polymerase, PSI-6130 must be phosphorylated to the 5'-triphosphate form. The ... |
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Structure-based functional identification of Helicobacter pylori HP0268 as a nuclease with both DNA nicking and RNase activities.
Nucleic Acids Res. 43 , 5194-207, (2015) HP0268 is a conserved, uncharacterized protein from Helicobacter pylori. Here, we determined the solution structure of HP0268 using three-dimensional nuclear magnetic resonance (NMR) spectroscopy, revealing that this protein is structurally most similar to a ... |
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Synthesis and characterization of a multimode stationary phase: Congo red derivatized silica in nano-flow HPLC.
Analyst 141 , 1083-90, (2016) A novel Congo red (CR) derivatized silica stationary phase was prepared and packed into a fused silica capillary tube for nano-flow HPLC. A variety of analytes including poly-aromatic hydrocarbons, parabens, acids, sulfonamides, bases, and nucleosides were su... |
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Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase.
Arch. Biochem. Biophys. 536(1) , 53-63, (2013) Cytidine monophosphate kinase from Mycobacterium tuberculosis (MtCMK) likely plays a role in supplying precursors for nucleic acid synthesis. MtCMK catalyzes the ATP-dependent phosphoryl group transfer preferentially to CMP and dCMP. Initial velocity studies ... |
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Nucleoside monophosphate kinases: structure, mechanism, and substrate specificity.
Adv. Enzymol. Relat. Areas Mol. Biol. 73 , 103-134, (1999) The catalytic mechanisms of adenylate kinase, guanylate kinase, uridylate kinase, and cytidylate kinase are reviewed in terms of kinetic and structural information that has been obtained in recent years. All four kinases share a highly related tertiary struct... |
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Methylation stabilizes the imino tautomer of dAMP and amino tautomer of dCMP in solution.
J. Phys. Chem. B 115(19) , 6234-42, (2011) Alkylating agents cause methylation of adenosine and cytidine in DNA to generate 1-methyladenosine and 3-methylcytidine. These modified nucleosides can serve as regulators of cells or can act as agents of mutagenesis depending on the context and the partner e... |
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Expanding the borononucleotide family: synthesis of borono-analogues of dCMP, dGMP and dAMP.
Org. Biomol. Chem. 7(21) , 4369-77, (2009) We previously reported the synthesis of a borononucleotide analogue of thymidine monophosphate and its association towards the formation of a new borono-linked dinucleotide. Here we describe the completion of the set of four 2'-deoxyborononucleotide analogues... |