Silybin
Silybin structure
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Common Name | Silybin | ||
|---|---|---|---|---|
| CAS Number | 802918-57-6 | Molecular Weight | 482.43600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H22O10 | Melting Point | 152-153°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.
J. Pharm. Pharmacol. 66(9) , 1339-46, (2014) The aim of this study is to establish the inhibitory effects of 14 commonly used complementary and alternative medicines (CAM) on the metabolism of cytochrome P450 2C9 (CYP2C9) substrates 7-methoxy-4-trifluoromethyl coumarine (MFC) and tolbutamide. CYP2C9 is ... |
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Engineered silybin nanoparticles educe efficient control in experimental diabetes.
PLoS ONE 9(7) , e101818, (2014) Silybin, is one imminent therapeutic for drug induced hepatotoxicity, human prostate adenocarcinoma and other degenerative organ diseases. Recent evidences suggest that silybin influences gluconeogenesis pathways favorably and is beneficial in the treatment o... |
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Isolation and purification of diastereoisomeric flavonolignans from silymarin by binary-column recycling preparative high-performance liquid chromatography.
J. Sep. Sci. 37(17) , 2300-6, (2014) Silymarin extracted from Silybum marianum (L.) Gaertn consists of a large number of flavonolignans, of which diastereoisomeric flavonolignans including silybin A and silybin B, and isosilybin A and isosilybin B are the main bioactive components, whose prepara... |
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Icaritin ameliorates carbon tetrachloride-induced acute liver injury mainly because of the antioxidative function through estrogen-like effects.
In Vitro Cell. Dev. Biol. Anim. 50(10) , 899-908, (2014) To investigate the effects of icaritin, an active ingredient extracted from Epimedium Sagittatum (Sieb. et Zucc.), on CCl4-induced liver injury and its possible mechanisms. Hepatocytes isolated from Sprague-Dawley male rats were treated with 3 mmol/L CCl4 for... |
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Evaluation of hepatocyteprotective and anti-hepatitis B virus properties of Cichoric acid from Cichorium intybus leaves in cell culture.
Biol. Pharm. Bull. 37(7) , 1214-20, (2014) Hepatitis B is the most common serious liver infection in the world. To date, there is still no complete cure for chronic hepatitis B. Natural caffeic acid analogues possess prominent antiviral activity, especially anti-hepatitis B virus (HBV) and anti-human ... |
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Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer MGC803 cells via STAT3 pathway inhibition.
Asian Pac. J. Cancer Prev. 15(16) , 6791-8, (2014) To investigate the effect of silibinin on proliferation and apoptosis in human gastric cancer cell line MGC803 and its possible mechanisms.Human gastric cancer cell line MGC803 cells were treated with various concentration of silibinin. Cellular viability was... |