4'-ACETAMIDOPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
4'-ACETAMIDOPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE structure
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Common Name | 4'-ACETAMIDOPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE | ||
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| CAS Number | 79119-49-6 | Molecular Weight | 348.78400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H17ClN4O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Inhibition of a tumour protease with 3,4-dichloroisocoumarin, pentamidine-isethionate and guanidino derivatives.
J. Enzym. Inhib. 8(3) , 213-21, (1994) Guanidinobenzoatase (GB) is a cell surface proteolytic enzyme capable of degrading fibronectin, and is associated with tumour cells and cells capable of migration. The location of active GB in sections has been demonstrated with 9-aminoacridine (9-AA), a comp... |
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Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates.
J. Med. Chem. 29 , 514, (1986) The aryl 4-guanidinobenzoate, 4'-nitrophenyl 4-guanidinobenzoate (NPGB), is a potent inhibitor of sperm acrosin, an enzyme with an essential function in the fertilization process. NPGB prevents fertilization in a number of animal species and is a good lead co... |
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Trypsin inhibitors prevent the progesterone-initiated increase in intracellular calcium required for the human sperm acrosome reaction.
J. Exp. Zool. 258(3) , 384-93, (1991) Inhibitors of trypsin-like enzymes, benzamidine hydrochloride and 4'-acetamidophenyl 4-guanidinobenzoate (also an inhibitor of other serine proteases), were tested for their effects on the acrosome reaction (AR) of human sperm initiated by progesterone or the... |
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Inhibition of the human sperm acrosome reaction by proteinase inhibitors.
Gamete Res. 23(4) , 387-97, (1989) The analogue of the second messenger cAMP, dibutyryl cAMP (dbcAMP), was shown to induce the human sperm acrosome reaction to the same extent as calcium ionophore A23187, providing preliminary evidence for the involvement of the adenylate cyclase system in the... |
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Characterization of acrosin-like activity of lake sturgeon (Acipenser fulvescens) spermatozoa.
Mol. Reprod. Dev. 45(1) , 72-7, (1996) Acipenserid fish sperm possess trypsin-like activity, resembling acrosin activity of mammalian sperm, which can be measured by hydrolysis of N-alpha-benzoyl-DL-arginine p-nitroanilide (BAPNA) (Ciereszko et al., 1994: J Exp Zool 268:486-491). We found that thi... |
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Acrosin inhibitor, 4'-acetamidophenyl 4-guanidinobenzoate, an experimental vaginal contraceptive with anti-HIV activity.
Contraception 51(5) , 319-22, (1995) Serine proteases are involved in a wide variety of seemingly unrelated physiological functions including capacitation of the spermatozoa and potentiation of human immunodeficiency virus (HIV) infection. The experimental vaginal contraceptives derived from 4-g... |
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Development of the polyurethane sponge as a delivery system for aryl 4-guanidinobenzoates.
Contraception 38(4) , 487-97, (1988) The Today Contraceptive Sponge was evaluated as a vehicle for the delivery of aryl 4-guanidinobenzoates (AGs) which are highly active sperm acrosin inhibitors. Studies in animals have shown that several AGs are more potent vaginal contraceptives and less irri... |