Isocitrate dehydrogenase
Isocitrate dehydrogenase structure
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Common Name | Isocitrate dehydrogenase | ||
|---|---|---|---|---|
| CAS Number | 9028-48-2 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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[Effect of glyphosate on the energy exchange in carp organs].
Ukr. Biokhim. Zh. 85(3) , 22-30, (2013) The use of glyphosate as a herbicide in agriculture can lead to the presence of its residues and metabolites (aminomethylphosphonic acid) in food for human consumption and pose a threat to health. The effect of these herbicides on the fish organism at the bio... |
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Genetic features of oligodendrogliomas and presence of seizures. The relationship of seizures and genetics in LGOs.
Clin. Neuropathol. 33(4) , 292-8, (2014) Low grade oligodendrogliomas (LGO) are diffusely infiltrating World Health Organization (WHO) grade II gliomas, 20 - 30% of which show contrast enhancement. Seizures are a common presenting feature. It has been suggested that 1p19q co-deletion is associated w... |
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Controversies over the diagnosis of oligodendroglioma: a report from the satellite workshop at the 4th international symposium of brain tumor pathology, Nagoya Congress Center, May 23, 2012.
Brain Tumor Pathol. 30(4) , 253-61, (2013) With the goal of discussing how the neuropathology community should resolve the controversy over the diagnosis of oligodendroglioma, this Satellite Workshop reflects the collaboration between two invited keynote speakers: Dr. Johan M. Kros of the Erasmus Medi... |
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Biochemical and phylogenetic characterization of isocitrate dehydrogenase from a hyperthermophilic archaeon, Archaeoglobus fulgidus.
Arch. Microbiol. 168(5) , 412-20, (1997) A thermostable homodimeric isocitrate dehydrogenase from the hyperthermophilic sulfate-reducing archaeon Archaeoglobus fulgidus was purified and characterized. The mol. mass of the isocitrate dehydrogenase subunit was 42 kDa as determined by SDS-PAGE. Followi... |
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Whole-genome thermodynamic analysis reduces siRNA off-target effects.
PLoS ONE 8(3) , e58326, (2013) Small interfering RNAs (siRNAs) are important tools for knocking down targeted genes, and have been widely applied to biological and biomedical research. To design siRNAs, two important aspects must be considered: the potency in knocking down target genes and... |
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WT1 expression increases with malignancy and indicates unfavourable outcome in astrocytoma.
J. Clin. Pathol. 67(7) , 556-61, (2014) The zinc finger transcription factor WT1 is expressed in astrocytic neoplasms and therefore is a potential target of immunotherapy in brain tumours. Our aim was to further elucidate the role of WT1 as a diagnostic and prognostic marker in neuropathology, part... |
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Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.
Biochemistry 52(26) , 4563-77, (2013) The human, cytosolic enzyme isocitrate dehydrogenase 1 (IDH1) reversibly converts isocitrate to α-ketoglutarate (αKG). Cancer-associated somatic mutations in IDH1 result in a loss of this normal function but a gain in a new or neomorphic ability to convert αK... |
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Impact of genetic targets on primary brain tumor therapy: what's ready for prime time?
Adv. Exp. Med. Biol. 779 , 267-89, (2013) Primary brain tumors constitute a substantial public health problem with 66,290 cases diagnosed in the US in 2012, and 13,700 deaths recorded. With discovery of genetic factors associated with specific brain tumor subtypes, the goal of therapy is changing fro... |
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Isocitrate dehydrogenases from Haloferax volcanii and Sulfolobus solfataricus: enzyme purification, characterisation and N-terminal sequence.
FEMS Microbiol. Lett. 134(1) , 85-90, (1995) The isocitrate dehydrogenases from the extremely halophilic Archaeon, Haloferax volcanii, and from the hyperthermophilic Archaeon, Sulfolobus solfataricus, have been purified to electrophoretic homogeneity. The purified enzymes have been characterised with re... |
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Subgrouping of gliomas on the basis of genetic profiles.
Brain Tumor Pathol. 30(4) , 203-8, (2013) Management of gliomas depends on histological diagnosis; there are, however, limitations to the systems presently used. Tumors in the same entity can have different clinical courses, especially when they are diagnosed as WHO grade II-III. Previous studies rev... |