Polyinosinic-polycytidylic acid sodium
Polyinosinic-polycytidylic acid sodium structure
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Common Name | Polyinosinic-polycytidylic acid sodium | ||
|---|---|---|---|---|
| CAS Number | 42424-50-0 | Molecular Weight | 694.4 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H27N7NaO16P2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.
Oncotarget 6 , 37678-94, (2015) Ewing sarcoma is an aggressive tumor of bone and soft tissue affecting predominantly children and young adults. Tumor-specific chromosomal translocations create EWS-FLI1 and similar aberrant ETS fusion proteins that drive sarcoma development in patients. ETS ... |
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WFDC1 is a key modulator of inflammatory and wound repair responses.
Am. J. Pathol. 184(11) , 2951-64, (2014) WFDC1/ps20 is a whey acidic protein four-disulfide core member that exhibits diverse growth and immune-associated functions in vitro. In vivo functions are unknown, although WFDC1 is lower in reactive stroma. A Wfdc1-null mouse was generated to assess core fu... |
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The broad pattern recognition spectrum of the Toll-like receptor in mollusk Zhikong scallop Chlamys farreri.
Dev. Comp. Immunol. 52 , 192-201, (2015) Toll-like receptors (TLRs) are among the most studied pattern recognition receptors (PRRs) playing essential roles in innate immune defenses. In the present study, the basic features of CfTLR in mollusk Zhikong scallop Chlamys farreri, including sequence homo... |
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Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice.
Leukemia 29 , 1032-40, (2015) The role of hyperactive RAS signaling is well established in myeloid malignancies but less clear in T-cell malignancies. The Kras2(LSL)Mx1-Cre (KM) mouse model expresses endogenous KRAS(G12D) in hematopoietic cells and is widely used to study mechanisms and t... |
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PKR activation enhances replication of classical swine fever virus in PK-15 cells.
Virus Res. 204 , 47-57, (2015) Classical swine fever (CSF) is a highly contagious swine disease that is responsible for economic losses worldwide. Protein kinase R (PK)R is an important protein in the host viral response; however, the role of PKR in CSFV infection remains unknown. This iss... |
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Mutational analysis of vaccinia virus E3 protein: the biological functions do not correlate with its biochemical capacity to bind double-stranded RNA.
J. Virol. 89(10) , 5382-94, (2015) Vaccinia E3 protein has the biochemical capacity of binding to double-stranded RNA (dsRNA). The best characterized biological functions of the E3 protein include its host range function, suppression of cytokine expression, and inhibition of interferon (IFN)-i... |
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Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome.
Nat. Commun. 6 , 6115, (2015) Excessive activation of the NLRP3 inflammasome results in damaging inflammation, yet the regulators of this process remain poorly defined. Herein, we show that the orphan nuclear receptor small heterodimer partner (SHP) is a negative regulator of NLRP3 inflam... |
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Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity.
J. Virol. 88(17) , 10066-77, (2014) We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 ... |
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Toll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane formation.
J. Neurosci. Res. 90(2) , 388-98, (2011) Toll-like receptors (TLRs) play a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules as well as endogenous signals. In addition, TLR expression within nonimmune cells has been recognized as as modulator of cell ... |
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Toll-like receptor 3-mediated tumor invasion in head and neck cancer.
Oral Oncol. 48(3 , 226-32, (2011) Chronic inflammation associated with some infectious agents can lead to cancer. The Toll-like receptor (TLR) family is one of the largest and best-studied families of pathogen-associated molecular patterns. TLR3 recognizes double-stranded RNA and is a major e... |