uricase
uricase structure
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Common Name | uricase | ||
|---|---|---|---|---|
| CAS Number | 9002-12-4 | Molecular Weight | 567.398 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H26N5O14P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Rasburicase in the prevention of laboratory/clinical tumour lysis syndrome in children with advanced mature B-NHL: a Children's Oncology Group Report.
Br. J. Haematol. 163(3) , 365-72, (2013) Laboratory (LTLS) and clinical (CTLS) tumour lysis syndrome (TLS) are frequent complications in newly diagnosed children with advanced mature B cell non-Hodgkin lymphoma (B-NHL). Rasburicase, compared to allopurinol, results in more rapid reduction of uric ac... |
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Resolution of massive tophaceous gout with three urate-lowering drugs.
Am. J. Med. 126(11) , e9-10, (2013)
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Reorganizing the protein space at the Universal Protein Resource (UniProt).
Nucleic Acids Res. 40 , D71-D75, (2012) The mission of UniProt is to support biological research by providing a freely accessible, stable, comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references and querying interfaces. UniPro... |
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Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration.
Proc. Natl. Acad. Sci. U. S. A. 110(1) , 300-5, (2013) Urate is the end product of purine metabolism in humans, owing to the evolutionary disruption of the gene encoding urate oxidase (UOx). Elevated urate can cause gout and urolithiasis and is associated with cardiovascular and other diseases. However, urate als... |
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Improved biological properties and hypouricemic effects of uricase from Candida utilis loaded in novel alkaline enzymosomes.
Int. J. Nanomedicine 7 , 3929-38, (2012) Previous studies on various enzymosomes (functional lipid vesicles encapsulating an enzyme) have been mostly carried out in vitro and have focused on preserving catalytic activity and improving the stability of the enzyme. Until now, few studies have focused ... |
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Purification and properties of solubilized uricase.
Biochim. Biophys. Acta 21(2) , 290-8, (1956)
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Studies on uricase. I. Preparation, purification, and properties of a cuproprotein.
J. Biol. Chem. 216(2) , 625-41, (1955)
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Partial pruficiation of procine liver uricase.
J. Biol. Chem. 216(1) , 27-35, (1955)
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Impact of large aggregated uricases and PEG diol on accelerated blood clearance of PEGylated canine uricase.
PLoS ONE 7 , e39659, (2012) Uricase has proven therapeutic value in treating hyperuricemia but sufficient reduction of its immunogenicity may be the largest obstacle to its chronic use. In this study, canine uricase was modified with 5 kDa mPEG-SPA and the impact of large aggregated uri... |
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A biohybrid hydrogel for the urate-responsive release of urate oxidase.
J. Control. Release 171(1) , 57-62, (2013) Functional biomaterials that detect and correct pathological parameters hold high promises for biomedical application. In this study we describe a biohybrid hydrogel that detects elevated concentrations of uric acid and responds by dissolution and the release... |