3,5-Di-tert-butyl-4-hydroxybenzoic acid
3,5-Di-tert-butyl-4-hydroxybenzoic acid structure
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Common Name | 3,5-Di-tert-butyl-4-hydroxybenzoic acid | ||
|---|---|---|---|---|
| CAS Number | 1421-49-4 | Molecular Weight | 250.33300 | |
| Density | 1.07 g/cm3 | Boiling Point | 340.6ºC at 760 mmHg | |
| Molecular Formula | C15H22O3 | Melting Point | 206-209 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 174ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Human exposure assessment to a large set of polymer additives through the analysis of urine by solid phase extraction followed by ultra high performance liquid chromatography coupled to tandem mass spectrometry.
J. Chromatogr. A. 1423 , 111-23, (2015) Polymer items are extensively present in the human environment. Humans may be consequently exposed to some compounds, such as additives, incorporated in these items. The objective of this work is to assess the human exposure to the main additives such as thos... |
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Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies.
Drug Des. Devel. Ther. 6 , 323-39, (2012) Human uric acid transporter 1 (hURAT1; SLC22A12) is a very important urate anion exchanger. Elevated urate levels are known to play a pivotal role in cardiovascular diseases, chronic renal disease, diabetes, and hypertension. Therefore, the development of pot... |
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Determination of synthetic phenolic antioxidants and their metabolites in water samples by downscaled solid-phase extraction, silylation and gas chromatography-mass spectrometry.
J. Chromatogr. A. 1217(41) , 6428-35, (2010) The development and performance evaluation of an analytical method dedicated to the comprehensive determination of the most relevant antioxidants and their metabolites in aqueous environmental samples is presented. This was achieved by a miniaturised solid-ph... |
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Novel compounds designed as antistress agents.
J. Med. Chem. 52 , 7315-8, (2009) Agents against biologic stress were designed, containing GABA esterified with lorazepam and amidated with (R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (5) or 3,5-di-tert-butyl-4-hydroxybenzoic acid (6). Compounds 5 and 6 inhibited lipid peroxida... |
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Disposition of single oral doses of butylated hydroxytoluene in man and rat.
Food Chem. Toxicol. 27(12) , 765-72, (1989) The kinetics and metabolism of butylated hydroxytoluene (BHT) in man and rats have been compared. Single oral doses of 200, 63 or 20 mg BHT/kg body weight were administered to rats and a single oral dose of 0.5 mg/kg body weight was ingested by human voluntee... |
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Synergistic protective effects of antioxidant and nitric oxide synthase inhibitor in transient focal ischemia.
J. Cereb. Blood Flow Metab. 19(2) , 139-43, (1999) Both nitric oxide synthase (NOS) inhibitors and free radical scavengers have been shown to protect brain tissue in ischemia-reperfusion injury. Nitric oxide and superoxide anion act via distinct mechanisms and react together to form the highly deleterious per... |
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Na(+)-translocating cytochrome bo terminal oxidase from Vitreoscilla: some parameters of its Na+ pumping and orientation in synthetic vesicles.
Biochemistry 35(36) , 11895-900, (1996) Vitreoscilla cytochrome bo ubiquinol oxidase is similar in some properties to the Escherichia coli enzyme, but unlike the latter, the Vitreoscilla oxidase functions as a primary Na+ pump. When purified Vitreoscilla cytochrome bo is incorporated into liposomes... |
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Further metabolism of 3,5-di-tert-butyl-4-hydroxybenzoic acid, a major metabolite of butylated hydroxytoluene, in rats.
Chem. Pharm. Bull. 39(2) , 512-4, (1991) The metabolic pathway of butylated hydroxytoluene (BHT) to the ring-oxygenated metabolites 2,6-di-tert-butylhydroquinone (BHQ) and 2,6-di-tert-butyl-p-benzoquinone (BBQ) was examined in rats. After intraperitoneal administration of 3,5-di-tert-butyl-4-hydroxy... |