trans-Glutaconic acid
trans-Glutaconic acid structure
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Common Name | trans-Glutaconic acid | ||
|---|---|---|---|---|
| CAS Number | 1724-02-3 | Molecular Weight | 130.099 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 413.8±28.0 °C at 760 mmHg | |
| Molecular Formula | C5H6O4 | Melting Point | 133-135ºC | |
| MSDS | Chinese USA | Flash Point | 218.2±20.5 °C | |
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Stereodifferentiation of 3-hydroxyisobutyric- and 3-aminoisobutyric acid in human urine by enantioselective multidimensional capillary gas chromatography-mass spectrometry.
Clin. Chim. Acta 292 , 93-105, (2000) The chiral metabolites 3-hydroxyisobutyric acid (HIBA) and 3-aminoisobutyric acid (AIBA) are intermediates in the pathways of L-valine and thymine and play an important role in the diagnosis of the very rare inherited metabolic diseases 3-hydroxyisobutyric ac... |
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Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids.
Biochem. Biophys. Res. Commun. 272(2) , 431-5, (2000) We recently reported that acrylic acid (AA) induces the MPT in vitro, which we suggested might be a critical event in the acute inflammatory and hyperplastic response of the olfactory epithelium. The purpose of the present investigation was to determine if in... |
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Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones.
J. Med. Chem. 51 , 4054-8, (2008) An efficient synthesis involving a key aldol reaction and biological properties of 1,3-diphenyl-2-propen-1-ones 8- 20 is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of 10 and 11 was 2 times higher than that for... |
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Neurotoxic effects of trans-glutaconic acid in rats.
Oxid. Med. Cell. Longev. 2013 , 607610, (2013) trans-Glutaconic acid (tGA) is an unsaturated C5-dicarboxylic acid which may be found accumulated in glutaric aciduria type I, whose pathophysiology is still uncertain. In the present work it was investigated the in vitro effect of increasing tGA concentratio... |
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Plausible molecular mechanism for activation by fumarate and electron transfer of the dopamine beta-mono-oxygenase reaction.
Biochem. J. 367(Pt 1) , 77-85, (2002) A series of fumarate analogues has been used to explore the molecular mechanism of the activation of dopamine beta-mono-oxygenase by fumarate. Mesaconic acid (MA) and trans -glutaconic acid (TGA) both activate the enzyme at low concentrations, similar to fuma... |
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Nerve cell lesions caused by 3-hydroxyglutaric acid: a possible mechanism for neurodegeneration in glutaric acidaemia I.
J. Inherit. Metab. Dis. 20(3) , 387-90, (1997)
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99mTc-labeling and in vitro and in vivo evaluation of HYNIC- and (Nalpha-His)acetic acid-modified [D-Glu1]-minigastrin.
Bioconjug. Chem. 15(4) , 864-71, (2004) Gastrin/CCK-2 receptors are overexpressed in a number of tumors such as medullary thyroid cancer (MTC) and small cell lung cancer (SCLC). Recently [D-Glu1]-minigastrin (MG) has been radiolabeled with 131I, 111In, and 90Y and evaluated in patients. This study ... |
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Glutaconate CoA-transferase from Acidaminococcus fermentans.
Eur. J. Biochem. 118(2) , 315-21, (1981) 1. Glutaconate CoA-transferase catalyses the transfer of CoAS- from acetyl-CoA preferentially to (E)-glutaconate, but glutarate, (R)-2-hydroxyglutarate, acrylate and propionate are also good acceptors. No reaction was observed with (Z)-glutaconate and C4-dica... |
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The reversible dehydration of (R)-2-hydroxyglutarate to (E)-glutaconate.
Eur. J. Biochem. 106(2) , 439-47, (1980) 1. During fermentation with whole cells of Acidaminococcus fermentans or Clostridium microsporum the pro-3S hydrogen of (R)-2-hydroxyglutarate or of its precursor (S)-glutamate is eliminated stereospecifically. Since (E)-glutaconate but not its Z isomer is fe... |
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On the neurotoxicity of glutaric, 3-hydroxyglutaric, and trans-glutaconic acids in glutaric acidemia type 1.
J. Neurosci. Res. 77(1) , 143-7, (2004) Glutaric acidemia type 1 (GA1) is an autosomal recessively inherited deficiency of glutaryl-CoA dehydrogenase. Accumulating metabolites, 3-hydroxyglutaric (3-OH-GA), glutaric (GA), and trans-glutaconic (TG) acids, have been proposed to be involved in the deve... |