PQ 401
PQ 401 structure
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Common Name | PQ 401 | ||
|---|---|---|---|---|
| CAS Number | 196868-63-0 | Molecular Weight | 341.792 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 426.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H16ClN3O2 | Melting Point | 190 °C(dec.) | |
| MSDS | Chinese USA | Flash Point | 211.5±28.7 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Identification of Novel IGF1R Kinase Inhibitors by Molecular Modeling and High-Throughput Screening.
Acta Naturae 5(2) , 90-9, (2013) The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to develop drug candidates that are superior to the existing experi... |
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IGFBP-2 directly stimulates osteoblast differentiation.
J. Bone Miner Res. 29(11) , 2427-38, (2014) Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differe... |
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Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.
Mol. Cancer Ther. 5 , 1079-1086, (2006) In breast and certain other cancers, receptor tyrosine kinases, including the insulin-like growth factor I receptor (IGF-IR), play an important role in promoting the oncogenic process. The IGF-IR is therefore an important target for developing new anti-breast... |
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Transcriptome sequencing identifies ETV6-NTRK3 as a gene fusion involved in GIST.
J. Pathol. 238 , 543-9, (2016) Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. The vast majority of GISTs are driven by oncogenic activation of KIT, PDGFRA or, less commonly, BRAF. Loss of succinate dehydrogenase complex act... |
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PQ401, an IGF-1R inhibitor, induces apoptosis and inhibits growth, proliferation and migration of glioma cells.
J. Chemother. 28 , 44-9, (2016) Growth factor signalling pathways transduce extra-cellular physiological cues to guide cells to maintain critical cellular functions, including cell proliferation, survival and metabolism. Dysregulation of certain growth factor signalling pathways has been sh... |
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Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells.
Lung Cancer 90 , 175-81, (2015) Lung cancer is the commonly diagnosed cancer and is the leading cause of cancer-related mortality worldwide. The most prevalent form of lung cancer is NSCLC, comprising 80% of all lung cancer cases, and epidermal growth factor receptor (EGFR) is frequently mu... |