Src Inhibitor-1
Src Inhibitor-1 structure
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Common Name | Src Inhibitor-1 | ||
|---|---|---|---|---|
| CAS Number | 179248-59-0 | Molecular Weight | 373.405 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 528.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H19N3O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 273.2±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.
Nat. Commun. 6 , 8100, (2015) Cholesterol biosynthesis is regulated by transcription factors SREBPs and their escort protein Scap. On sterol depletion, Scap/SREBP complex is transported from endoplasmic reticulum (ER) to the Golgi apparatus where SREBP is activated. Under cholesterol suff... |
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Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.
J. Hepatol. 62 , 1367-74, (2015) Sustained c-Jun N-terminal kinase (JNK) activation by saturated fatty acids plays a role in lipotoxicity and the pathogenesis of non-alcoholic steatohepatitis (NASH). We have reported that the interaction of JNK with mitochondrial Sab leads to inhibition of r... |
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Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3.
Exp. Hematol. 42(9) , 773-82.e1-3, (2014) The SRC family of kinases (SFKs) is crucial to malignant growth, but also important for signaling in immune cells such as dendritic cells (DCs). These specialized antigen-presenting cells are essential for inducing and boosting specific T-cell responses again... |
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Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells.
Cancer Res. 68(12) , 4640-8, (2008) Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three different human malignancies, including Kaposi's sarcoma (KS), primary effusion lymphoma, and multicentric Castleman's disease. The KS lesion is of endothelial cell in origin and is highl... |
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Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.
J. Cell Biol. 210 , 503-15, (2015) The Hippo pathway is involved in the regulation of contact inhibition of proliferation and responses to various physical and chemical stimuli. Recently, several upstream negative regulators of Hippo signaling, including epidermal growth factor receptor ligand... |
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The selectivity of protein kinase inhibitors: a further update.
Biochem. J. 408 , 297-315, (2007) The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases. On the basis of this information, the effects of compounds that we have studied in cells and other ... |
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7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.
J. Med. Chem. 47(7) , 1599-601, (2004) We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase. |
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Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.
Arthritis Rheumatology 68 , 117-26, (2015) Oxidative posttranslational modifications of intracellular proteins can potentially regulate signaling pathways relevant to cartilage destruction in arthritis. In this study, oxidation of cysteine residues to form sulfenic acid (S-sulfenylation) was examined ... |