Flunitrazepam
Flunitrazepam structure
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Common Name | Flunitrazepam | ||
|---|---|---|---|---|
| CAS Number | 1622-62-4 | Molecular Weight | 313.28300 | |
| Density | 1.39g/cm3 | Boiling Point | 540.9ºC at 760mmHg | |
| Molecular Formula | C16H12FN3O3 | Melting Point | 166-167ºC | |
| MSDS | Chinese USA | Flash Point | 280.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Determination of low levels of benzodiazepines and their metabolites in urine by hollow-fiber liquid-phase microextraction (LPME) and gas chromatography-mass spectrometry (GC-MS).
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 975 , 24-33, (2014) In this study, it is shown a method for the determination of benzodiazepines and their main metabolites in urine samples by hollow-fiber liquid-phase microextraction (LPME) in the three-phase mode. Initially, the hydrolysis step was performed using 100 μL of ... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).
Forensic Sci. Int. 243 , 99-106, (2014) The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-residue pesticide analysis in food and agricultural products. ... |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
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Across-Species Transfer of Protection by Remote Ischemic Preconditioning With Species-Specific Myocardial Signal Transduction by Reperfusion Injury Salvage Kinase and Survival Activating Factor Enhancement Pathways.
Circ. Res. 117 , 279-88, (2015) Reduction of myocardial infarct size by remote ischemic preconditioning (RIPC), that is, cycles of ischemia/reperfusion in an organ remote from the heart before sustained myocardial ischemia/reperfusion, was confirmed in all species so far, including humans.T... |
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Calibration of pre-equilibrium HF-LPME and its application to the rapid determination of free analytes in biological fluids.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 28-33, (2015) This study establishes a novel calibration method for pre-equilibrium hollow-fiber liquid-phase microextraction (PE-HF-LPME), where the time constant of the extraction of the analyte from sample matrix to the extraction phase (organic solvent) is obtained fro... |
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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug Metab. Dispos. 36 , 1385-405, (2008) We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data. This data set provides the drug metabolism scientist ... |
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Urine Mescaline Screening With a Biochip Array Immunoassay and Quantification by Gas Chromatography-Mass Spectrometry.
Ther. Drug Monit. 37 , 805-11, (2015) Mescaline, the primary psychoactive chemical in peyote cactus, has been consumed for thousands of years in ancient religious ceremonies. The US military wanted to determine if mescaline intake was a problem for personnel readiness. Twenty thousand seventeen u... |
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Solid-phase dispersive extraction method for analysis of benzodiazepine drugs in serum and urine samples.
J. Pharm. Biomed. Anal. 100 , 28-32, (2014) A simple yet highly efficient pretreatment method called solid-phase dispersive extraction (SPDE) was developed and used in combination with liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS) for the analysis of benzodiazepines (BZPs) in serum... |
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Identification and quantification of 34 drugs and toxic compounds in blood, urine, and gastric content using liquid chromatography with tandem mass spectrometry.
J. Sep. Sci. 38 , 1680-90, (2015) A liquid chromatography with tandem mass spectrometry method was developed for the simultaneous screening of 34 drugs and poisons in forensic cases. Blood (0.5 mL, diluted 1:1 with water) or 1.0 mL of urine was purified by solid-phase extraction. Gastric cont... |