Ramatroban
Ramatroban structure
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Common Name | Ramatroban | ||
|---|---|---|---|---|
| CAS Number | 116649-85-5 | Molecular Weight | 416.466 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 654.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C21H21FN2O4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 349.7±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats.
Eur. J. Pharmacol. 554(2-3) , 229-34, (2007) This study was undertaken to investigate the interactive effect of histamine and prostaglandin D(2) in nasal allergic symptoms in rats. The intranasal application of histamine at doses lower than 10 mumol/site caused no sneezing or nasal rubbing. In addition,... |
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IL-16 variability and modulation by antiallergic drugs in a murine experimental allergic rhinitis model.
Int. Arch. Allergy Immunol. 149(4) , 315-22, (2009) Interleukin-16 (IL-16) is a cytokine that induces selective migration of CD4+ cells and participates in inflammatory diseases including allergic rhinitis. Histamine and prostaglandin D(2) are important chemical mediators of allergic inflammation, and antialle... |
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Successful treatment of eosinophilic otitis media using ramatroban: report of two cases.
Auris. Nasus. Larynx. 33(4) , 455-60, (2006) The pathogenesis of eosinophilic otitis media is not yet fully understood. The purpose of this paper is to describe the clinical course of our two patients with eosinophilic otitis media and to discuss the pathogenesis and treatment of this intractable condit... |
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Prophylactic effects of the histamine H1 receptor antagonist epinastine and the dual thromboxane A2 receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells antagonist ramatroban on allergic rhinitis model in mice.
Biol. Pharm. Bull. 34(4) , 507-10, (2011) The prophylactic use of anti-allergic drugs has been proposed to be effective in the treatment of seasonal allergic rhinitis in humans. However, there is little information regarding the prophylactic effect of thromboxane A(2) (TXA(2)) receptor antagonist on ... |
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Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis.
Pharmacology 75(2) , 76-86, (2005) Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by histamine, leukotrienes, and other substances released from mast cells. Fexofenadine hydrochloride, the active metabolite of terfenadine, is a novel, nonsedating antiallergic drug ha... |
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Involvement of cyclooxygenase-2 in allergic nasal inflammation in rats.
Int. Immunopharmacol. 6(11) , 1736-42, (2006) This study was undertaken to investigate the involvement of cyclooxygenase-2 (COX-2) in allergic nasal inflammation in actively sensitized rats. An allergic rhinitis model was developed by the repeated topical application of antigen into the nasal cavities in... |
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Induction of apoptosis in non-small cell lung carcinoma A549 cells by PGD₂ metabolite, 15d-PGJ₂.
Cell Biol. Int. 35(11) , 1089-96, (2011) PGD2 (prostaglandin D2) is a mediator in various pathophysiological processes, including inflammation and tumorigenesis. PGD2 can be converted into active metabolites and is known to activate two distinct receptors, DP (PGD2 receptor) and CRTH2/DP2 (chemoattr... |
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Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5.
Inflamm. Res. 58(2) , 103-8, (2009) Prostaglandin D(2) (PGD(2)) has been shown to cause eosinophil, basophil and Th2 cell chemotaxis in vitro and in vivo through an action on the prostaglandin CRTH2 receptor. In the present study, the dependence of PGD(2)-induced eosinophil accumulation in vivo... |
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Prostaglandin D₂ receptor CRTH2 antagonists for the treatment of inflammatory diseases.
Prog. Med. Chem. 50 , 49-107, (2011)
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[CRTH2 antagonist ameliorates airway inflammation in rats with asthma].
Zhejiang Da Xue Xue Bao. Yi Xue Ban 39(1) , 64-70, (2010) To investigate the effect of prostaglandin D2 receptor antagonists on the airway inflammation in rats with asthma.Forty male SD rats were randomly divided into four groups: Group A (normal control), Group B (asthma group), Group C (CRTH2 antagonist BAYu3405 t... |