Salermide
Salermide structure
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Common Name | Salermide | ||
|---|---|---|---|---|
| CAS Number | 1105698-15-4 | Molecular Weight | 394.465 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 666.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C26H22N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 357.0±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts.
Biochim. Biophys. Acta 1850(2) , 401-10, (2015) Psammaplin A (PsA) is a natural product isolated from marine sponges, which has been demonstrated to have anticancer activity against several human cancer cell lines via the induction of cell cycle arrest and apoptosis. New drugs that are less toxic and more ... |
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Antiasthmatic effects of resveratrol in ovalbumin-induced asthma model mice involved in the upregulation of PTEN.
Biol. Pharm. Bull. 38(4) , 507-13, (2015) Resveratrol, a natural polyphenolic compound known for its antioxidative and antiinflammatory effects, exerts antiasthmatic effects, although the mechanism underlying these effects remains elusive. The phosphatase and tensin homology deleted on chromosome ten... |
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A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.
EMBO Mol. Med. 4(4) , 298-312, (2012) Although ∼50% of all types of human cancers harbour wild-type TP53, this p53 tumour suppressor is often deactivated through a concerted action by its abnormally elevated suppressors, MDM2, MDMX or SIRT1. Here, we report a novel small molecule Inauhzin (INZ) t... |
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A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer.
J. Biol. Chem. 289(8) , 5208-16, (2014) Sirtuin 2 (SIRT2) is an NAD(+)-dependent protein deacetylase whose targets include histone H4 lysine 16, p53, and α-tubulin. Because deacetylation of p53 regulates its effect on apoptosis, pharmacological inhibition of SIRT2-dependent p53 deacetylation is of ... |
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Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.
Vascul. Pharmacol. 56(1-2) , 64-73, (2012) Arterial remodeling contributes to elevated pulmonary artery (PA) pressures and right ventricular hypertrophy seen in pulmonary hypertension (PH). Resveratrol, a sirtuin-1 (SIRT1) pathway activator, can prevent the development of PH in a commonly used animal ... |
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Combination of Salermide and Cholera Toxin B Induce Apoptosis in MCF-7 but Not in MRC-5 Cell Lines.
Int. J. Prev. Med. 4 , 1402-13, (2014) Sirtuin1 is an enzyme that deacetylates histones and several non-histone proteins including P53 during the stress. P300 is a member of the histone acetyl transferase family and enzyme that acetylates histones. Hereby, this study describes the potency combinat... |
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The apoptotic effects of sirtuin1 inhibitor on the MCF-7 and MRC-5 cell lines.
Res. Pharm. Sci. 8 , 79-89, (2013) Sirtuin1 (SIRT1) is an enzyme that deacetylates histones and several nonhistone proteins including p53 during stress and plays an important role in the survival of tumor cells. Hereby, this study describes the potency of salermide as a SIRT1 inhibitor to indu... |
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Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets.
PLoS Negl. Trop. Dis. 7 , e2428, (2013) The chemotherapy of schistosomiasis currently depends on the use of a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in the epigenetic modification of chromatin. Sirtuins are NAD+ dependent l... |
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Deacetylation of H4-K16Ac and heterochromatin assembly in senescence.
Epigenetics Chromatin 5 , 15, (2012) Cellular senescence is a stress response of mammalian cells leading to a durable arrest of cell proliferation that has been implicated in tumor suppression, wound healing, and aging. The proliferative arrest is mediated by transcriptional repression of genes ... |
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Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells.
J. Cell. Mol. Med. 16 , 1618-28, (2012) Sirtuins (a class III histone deacetylase) have emerged as novel targets for cancer therapy. Salermide, a reverse amide compound that inhibits Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2), has been shown to induce apoptosis in human cancer cells. The mechanism und... |