SB216763
SB216763 structure
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Common Name | SB216763 | ||
|---|---|---|---|---|
| CAS Number | 280744-09-4 | Molecular Weight | 371.217 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 598.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C19H12Cl2N2O2 | Melting Point | 287-288.6ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 315.5±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Lenticular mitoprotection. Part B: GSK-3β and regulation of mitochondrial permeability transition for lens epithelial cells in atmospheric oxygen.
Mol. Vis. 19 , 2451-67, (2013) Loss of integrity of either the inner or outer mitochondrial membrane results in the dissipation of the mitochondrial electrochemical gradient that leads to mitochondrial membrane permeability transition (mMPT). This study emphasizes the role of glycogen synt... |
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Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome.
PLoS ONE 6(9) , e24648, (2011) Traumatic brain injury (TBI) sets in motion cascades of biochemical changes that result in delayed cell death and altered neuronal architecture. Studies have demonstrated that inhibition of glycogen synthase kinase-3 (GSK-3) effectively reduces apoptosis foll... |
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Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.
J. Neurochem. 77 , 94-102 , (2001) The phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (PKB; also known as Akt) signalling pathway is recognized as playing a central role in the survival of diverse cell types. Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/t... |
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Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes.
Stroke 40(2) , 652-5, (2009) We recently reported that delayed lithium therapy can improve stroke recovery in rats by augmenting neurovascular remodeling. We tested the hypothesis that lithium can promote the expression of growth factors in brain endothelial cells and astrocytes.Human br... |
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Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion.
Am. J. Physiol. Heart Circ. Physiol. 294(3) , H1497-500, (2008) Previous studies in our laboratory suggest that an acute inhibition of glycogen synthase kinase 3 (GSK3) by SB-216763 (SB21) is cardioprotective when administered just before reperfusion. However, it is unknown whether the GSK inhibitor SB21 administered 24 h... |
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Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.
Biochem. Biophys. Res. Commun. 334(4) , 1365-73, (2005) Glycogen synthase kinase 3beta (GSK3beta) reportedly has opposing roles, repressing Wnt/beta-catenin signaling on the one hand but maintaining cell survival and proliferation through the NF-kappaB pathway on the other. The present investigation was undertaken... |
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Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.
J. Neurosci. , 3456-67, (2008) Wnt proteins are conserved axon guidance cues that control growth cone navigation. However, the intracellular signaling mechanisms that mediate growth cone turning in response to Wnts are unknown. We previously showed that Wnt-Frizzled signaling directs spina... |
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Inhibition of glycogen synthase kinase-3beta is sufficient for airway smooth muscle hypertrophy.
J. Biol. Chem. , 10198-207, (2008) We examined the role of glycogen synthase kinase-3beta (GSK-3beta) inhibition in airway smooth muscle hypertrophy, a structural change found in patients with severe asthma. LiCl, SB216763, and specific small interfering RNA (siRNA) against GSK-3beta, each of ... |
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Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.
FASEB J. 30 , 983-93, (2016) Individuals with schizophrenia and their first-degree relatives have higher rates of type 2 diabetes (T2D) than the general population (18-30 vs. 1.2-6.3%), independent of body mass index and antipsychotic medication, suggesting shared genetic components may ... |
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Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology.
Respir. Res. 14 , 113, (2014) Glycogen synthase kinase-3 (GSK-3) is a constitutively active kinase that regulates multiple signalling proteins and transcription factors involved in a myriad of cellular processes. The kinase acts as a negative regulator in β-catenin signalling and is criti... |