SB 205384
SB 205384 structure
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Common Name | SB 205384 | ||
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| CAS Number | 160296-13-9 | Molecular Weight | 330.40 | |
| Density | 1.38g/cm3 | Boiling Point | 565.3ºC at 760 mmHg | |
| Molecular Formula | C17H18N2O3S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 295.7ºC | |
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Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice.
Mamm. Genome 21(5-6) , 247-57, (2010) The Tail Suspension Test (TST), which measures behavioral despair, is widely used as an animal model of human depressive disorders and antidepressant efficacy. In order to identify novel genes involved in the regulation of TST performance, we crossed an inbre... |
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Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons.
J. Physiol. 522 Pt 1 , 3-17, (2000) We examined the maturation of GABAA receptor synapses in cortical pyramidal neurons cultured from embryonic rats. The decay kinetics of GABAA receptor-mediated miniature postsynaptic currents (mPSCs) were compared with those of responses evoked by GABA in exc... |
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SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows subunit selectivity.
Br. J. Pharmacol. 123 , 1253-1259, (1998) 1. SB-205384, and its (+) enantiomer (+)-SB-205384 were tested for their modulatory effects on human GABA(A) receptor subunit combinations expressed in Xenopus oocytes by electrophysiological methods. 2. The slowing of the decay rate induced by SB-205384 on n... |
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Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum.
Br. J. Pharmacol. 121 , 1334-1338, (1997) 1. 4-Amino-7-hydroxy-2-methyl-5,6,7,8,-tetrahydrobenzo[b]thieno[2,3-b]pyrid ine-3-carboxylic acid, but-2-ynyl ester (SB-205384) and other gamma-aminobutyric acid(A) (GABA(A)) receptor modulators were tested for their effects on GABA-activated chloride current... |
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Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition.
J. Neurophysiol. 104(5) , 2321-8, (2010) Adaptive changes in hypothalamic neural circuitry occur in response to alterations in nutritional status. This plasticity at hypothalamic synapses contributes to the control of food intake and body weight. Here we show that genetic ablation of leptin receptor... |
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Inhibitory transmission in locus coeruleus neurons expressing GABAA receptor epsilon subunit has a number of unique properties.
J. Neurophysiol. 102(4) , 2312-25, (2009) Fast inhibitory synaptic transmission in the brain relies on ionotropic GABA(A) receptors (GABA(A)R). Eighteen genes code for GABA(A)R subunits, but little is known about the epsilon subunit. Our aim was to identify the synaptic transmission properties displa... |
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SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits.
J. Pharmacol. Exp. Ther. , (2013) Many drugs used to treat anxiety are positive modulators of GABAA receptors, which mediate fast inhibitory neurotransmission. The GABAA receptors can be assembled from a combination of at least 16 different subunits. The receptor's subunit composition determi... |
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Diversity of GABA(A) receptor synaptic currents on individual pyramidal cortical neurons.
Eur. J. Neurosci. 25(3) , 723-34, (2007) Miniature GABA(A) receptor-mediated inhibitory postsynaptic currents (mIPSCs) in cortical pyramidal neurons have previously been categorized into two types: small amplitude mIPSCs with a mono-exponential deactivation (mono-mIPSCs) and relatively larger mIPSCs... |
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Effects of SB-205384, a positive modulator of alpha3-subunit-containing GABA-A receptors, on isolation-induced aggression in male mice.
Psicothema 20(1) , 144-7, (2008) GABA-A receptors are involved in the control of aggressive behaviour. Various studies suggest a role for a1-containing GABA-A receptors in modulating aggression. However, the possible involvement of a3 subunit of GABA-A receptors has not been examined. In thi... |
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Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice.
Psicothema 18(1) , 100-4, (2006) Recent studies point to a major role for alpha2-containing GABA-A receptors in modulating anxiety. However, the possible implication of GABA-A receptors containing the alpha3 subunit on anxiety is less known. The aim of this study was to examine the effects o... |