SB 205384
SB 205384 structure
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Common Name | SB 205384 | ||
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| CAS Number | 160296-13-9 | Molecular Weight | 330.40 | |
| Density | 1.38g/cm3 | Boiling Point | 565.3ºC at 760 mmHg | |
| Molecular Formula | C17H18N2O3S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 295.7ºC | |
Use of SB 205384SB-205384 is a GABAA receptor modulator. The primary effect of SB-205384 on GABAA-activated currents is a prolonged response decay half-life upon removal of the agonist[1]. |
| Name | but-2-ynyl 4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-b]pyridine-3-carboxylate |
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| Description | SB-205384 is a GABAA receptor modulator. The primary effect of SB-205384 on GABAA-activated currents is a prolonged response decay half-life upon removal of the agonist[1]. |
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| Related Catalog | |
| References |
| Density | 1.38g/cm3 |
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| Boiling Point | 565.3ºC at 760 mmHg |
| Molecular Formula | C17H18N2O3S |
| Molecular Weight | 330.40 |
| Flash Point | 295.7ºC |
| Exact Mass | 330.10400 |
| PSA | 113.68000 |
| LogP | 2.79780 |
| Vapour Pressure | 1.29E-13mmHg at 25°C |
| Index of Refraction | 1.691 |
| InChIKey | JDTZAGLGBRRCJT-UHFFFAOYSA-N |
| SMILES | CC#CCOC(=O)c1c(C)nc2sc3c(c2c1N)CCC(O)C3 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice.
Mamm. Genome 21(5-6) , 247-57, (2010) The Tail Suspension Test (TST), which measures behavioral despair, is widely used as an animal model of human depressive disorders and antidepressant efficacy. In order to identify novel genes involve... |
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Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons.
J. Physiol. 522 Pt 1 , 3-17, (2000) We examined the maturation of GABAA receptor synapses in cortical pyramidal neurons cultured from embryonic rats. The decay kinetics of GABAA receptor-mediated miniature postsynaptic currents (mPSCs) ... |
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SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows subunit selectivity.
Br. J. Pharmacol. 123 , 1253-1259, (1998) 1. SB-205384, and its (+) enantiomer (+)-SB-205384 were tested for their modulatory effects on human GABA(A) receptor subunit combinations expressed in Xenopus oocytes by electrophysiological methods.... |