Efaroxan hydrochloride
Efaroxan hydrochloride structure
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Common Name | Efaroxan hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 89197-00-2 | Molecular Weight | 252.740 | |
| Density | N/A | Boiling Point | 387ºC at 760 mmHg | |
| Molecular Formula | C13H17ClN2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 187.9ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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In vivo evaluation of a new ¹⁸F-labeled PET ligand, [¹⁸F]FEBU, for the imaging of I₂-imidazoline receptors.
Nucl. Med. Biol. 42(4) , 406-12, (2015) The functions of I₂-imidazoline receptors (I₂Rs) are unknown, but evidence exists for their involvement in various neuropsychiatric disorders. Although a few positron emission tomography (PET) I₂R ligands have been developed, of which [(11)C]FTIMD and [(11)C]... |
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Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons.
Mol. Psychiatry 19(7) , 823-33, (2014) 3,4-Methylenedioxymethamphetamine (MDMA or 'ecstasy') is a psychostimulant drug, widely used recreationally among young people in Europe and North America. Although its neurotoxicity has been extensively described, little is known about its ability to strengt... |
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Evidence for imidazoline receptors involvement in the agmatine antidepressant-like effect in the forced swimming test.
Eur. J. Pharmacol. 565(1-3) , 125-31, (2007) This study investigated the involvement of the imidazoline receptors in the antidepressant-like effect of agmatine in the forced swimming test. The antidepressant-like effects of agmatine (10 mg/kg, i.p.) in the forced swimming test was blocked by pretreatmen... |
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Stimulatory effect of allantoin on imidazoline I₁ receptors in animal and cell line.
Horm. Metab. Res. 44(12) , 879-84, (2012) Allantoin is known as the agonist of imidazoline receptor, especially the I₂ subtype. Effect of allantoin on imidazoline I₁ receptor (I₁R) relating to reduction of blood pressure and its merit in steatosis are still obscure. Also, farnesoid X receptor (FXR) p... |
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Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?
Diabetologia 55(11) , 3071-82, (2012) Inspired by recent speculation about the potential utility of α(2A)-antagonism in the treatment of type 2 diabetes, the study examined the contribution of α(2)-antagonism vs other mechanisms to the antihyperglycaemic activity of the imidazoline (±)-efaroxan.E... |
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Quantification of very low enantiomeric impurity of efaroxan using a dual cyclodextrin system by capillary electrophoresis.
Anal. Chim. Acta 592(2) , 139-45, (2007) A rapid method for the enantiomeric purity determination of efaroxan has been developed by capillary electrophoresis (CE) using a dual cyclodextrin (CD) system. The influence of the nature and the concentration of CDs on separation parameters has been studied... |
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Validation of a method using an achiral liquid chromatography sorbent and a circular dichroism detector. Analysis of the efaroxan enantiomers.
J. Chromatogr. A. 1141(2) , 244-50, (2007) The known HPLC method using an achiral C8 silica sorbent and a circular dichroism (CD) detector for the determination of efaroxan enantiomeric excess has been validated. After optimization of the mobile phase, the enantiomers were detected at 278 nm offering ... |
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Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects.
Eur. J. Pharmacol. 553(1-3) , 73-81, (2006) Some studies, suggesting the involvement of I(2)-imidazoline binding sites (I(2)-IBS) in morphine analgesia modulation, prompted us to examine on mice antinociceptive assays the effect produced by 1 (phenyzoline), that in view of its high I(2)-IBS affinity an... |
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Preventive mechanisms of agmatine against ischemic acute kidney injury in rats.
Eur. J. Pharmacol. 603(1-3) , 108-13, (2009) The excitation of renal sympathetic nervous system plays an important role in the development of ischemic acute kidney injury in rats. Recently, we found that agmatine, an adrenaline alpha(2)/imidazoline I(1)-receptor agonist, has preventive effects on ischem... |
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Possible role of NMDA receptors in antinociception induced by rilmenidine in mice in the formalin test.
Eur. J. Pain 11(5) , 535-41, (2007) The aim of the study was to investigate the possible role of MK-801, an NMDA antagonist, in analgesia induced by rilmenidine, an imidazoline (I(1)) agonist, in mice in the formalin test.25 microl of formalin 2.5% was injected into the dorsal surface of the ri... |