Benzamidine Structure
Share to Facebook Share to Twitter Share to Linkedin
Common Name Benzamidine
CAS Number 618-39-3 Molecular Weight 120.152
Density 1.1±0.1 g/cm3 Boiling Point 208.5±23.0 °C at 760 mmHg
Molecular Formula C7H8N2 Melting Point 65-70ºC
MSDS Chinese USA Flash Point 79.9±22.6 °C
Symbol GHS07
Signal Word Warning

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.

Biochem. J. 467(2) , 345-52, (2015)

Ubiquitylation regulates a multitude of biological processes and this versatility stems from the ability of ubiquitin (Ub) to form topologically different polymers of eight different linkage types. Whereas some linkages have been studied in detail, other link...

The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.

PLoS Genet. 10(9) , e1004659, (2014)

The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various subst...

LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.

PLoS ONE 10(2) , e0118662, (2015)

In budding yeast, the Mitotic Exit Network (MEN) regulates anaphase promoting complex/cyclosome (APC/C) via the Dbf2-Cdc14 signaling cascade. Dbf2 kinase phosphorylates and activates Cdc14 phosphatase, which removes the inhibitory phosphorylation of the APC/C...

Stretch-stimulated glucose transport in skeletal muscle is regulated by Rac1.

J. Physiol. 593(3) , 645-56, (2015)

Rac1 regulates stretch-stimulated (i.e. mechanical stress) glucose transport in muscle. Actin depolymerization decreases stretch-induced glucose transport in skeletal muscle. Rac1 is a required part of the mechanical stress-component of the contraction-stimul...

Dimethyl sulphoxide and Ca2+ stimulate assembly of Vibrio cholerae FtsZ.

Biochimie 105 , 64-75, (2014)

We cloned, overexpressed and purified Vibrio cholerae FtsZ protein for the first time. We used several complementary techniques to probe and compare the comparative assembly properties of recombinant Vibrio cholerae FtsZ (VcFtsZ) and Escherichia coli FtsZ (Ec...

Differential signaling by regulatory subunits of phosphoinositide-3-kinase influences cell survival in INS-1E insulinoma cells.

Exp. Clin. Endocrinol. Diabetes 123(2) , 118-25, (2015)

Class 1A phosphoinositide 3-kinase (PI3K) is essential for beta-cell growth and survival. Although PI3K has been studied extensively in diabetes the effect of alternatively spliced isoforms of the catalytic subunit p85α on beta cell proliferation and survival...

Insights from reconstitution reactions of COPII vesicle formation using pure components and low mechanical perturbation.

Biol. Chem. 395(7-8) , 801-12, (2014)

As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factors constitutes an experimental challenge, however, because b...

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling.

Oncotarget 5(23) , 12126-40, (2015)

CYLD, an ubiquitin hydrolase, has an expanding repertoire of regulatory roles in cell signalling and is dysregulated in a number of cancers. To dissect CYLD function we used a proteomics approach to identify CYLD interacting proteins and identified MIB2, an u...

A gene signature of bone metastatic colonization sensitizes for tumor-induced osteolysis and predicts survival in lung cancer.

Oncogene 33(43) , 5090-9, (2014)

Bone metastasis of lung adenocarcinoma (AC) is a frequent complication of advanced disease. The purpose of this study was to identify key mediators conferring robust prometastatic activity with clinical significance. We isolated highly metastatic subpopulatio...

Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling.

Biochem. Biophys. Res. Commun. 453(4) , 778-83, (2015)

A lack of the REDD1 promotes dysregulated growth signaling, though little has been established with respect to the metabolic role of REDD1. Therefore, the goal of this study was to determine the role of REDD1 on glucose and insulin tolerance, as well as insul...