7-Methoxycoumarin
7-Methoxycoumarin structure
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Common Name | 7-Methoxycoumarin | ||
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| CAS Number | 531-59-9 | Molecular Weight | 176.169 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 335.3±37.0 °C at 760 mmHg | |
| Molecular Formula | C10H8O3 | Melting Point | 117-121 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 138.6±21.1 °C | |
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Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.
Regul Toxicol Pharmacol 72 , 578-85, (2015) Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic ingredients, such as plant extracts and polymers, could not b... |
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An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.
J. Nat. Prod. 73 , 1193-5, (2010) Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of esta... |
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7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro.
Anticancer Res. 33(10) , 4347-56, (2013) Coumarins are a large group of naturally-occurring compounds with a wide range of biological properties, including anticancer activity. 7-Substituted coumarins (umbelliferone, scoparone, and herniarin) were analyzed for their potential anticancer activity aga... |
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Decoding the anti-Trypanosoma cruzi action of HIV peptidase inhibitors using epimastigotes as a model.
PLoS ONE 9(12) , e113957, (2014) Aspartic peptidase inhibitors have shown antimicrobial action against distinct microorganisms. Due to an increase in the occurrence of Chagas' disease/AIDS co-infection, we decided to explore the effects of HIV aspartic peptidase inhibitors (HIV-PIs) on Trypa... |
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Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase.
Bioorg. Med. Chem. 20 , 1251-8, (2012) Data on phytochemical constituents of plants commonly used in traditional Indonesian medicine have been compiled as a computer database. This database (the Indonesian Herbal constituents database, IHD) currently contains details on ∼1,000 compounds found in 3... |
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Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
J. Med. Chem. 53 , 335-44, (2010) Coumarin derivatives were recently shown to constitute a totally new class of inhibitors of the zinc metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), being hydrolyzed within the CA active site to 2-hydroxycinnamic acids. We explore here a new series of vari... |
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Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination.
J. Med. Chem. 54 , 2331-40, (2011) Myelination represents one of the most fundamental biological processes in the vertebrate nervous system. Abnormalities and changes in myelination in the central nervous system (CNS) are seen in many neurodegenerative disorders, such as multiple sclerosis (MS... |
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Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.
Bioorg. Med. Chem. 20 , 784-8, (2012) The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins in... |
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6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.
Bioorg. Med. Chem. Lett. 20 , 5630-3, (2010) We report the structure-activity relationship of a series of coumarins as aldose reductase 2 (ALR2) inhibitors and their suppressive effect on the accumulation of galactitol in the rat lens. We evaluated their ALR2 selectivity profile against sorbitol dehydro... |
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Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.
Bioorg. Med. Chem. Lett. 20 , 3717-20, (2010) By use of the fission yeast expressing the model fusion protein comprised of GST, SV40 T antigen NLS, GFP, and Rev-NES in the bioassay, the prenylcoumarin osthol (1) was disclosed as the new Rev-export inhibitor from the MeOH extract of Cnidii Monnieris Fruct... |