Kynurenic acid
Kynurenic acid structure
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Common Name | Kynurenic acid | ||
|---|---|---|---|---|
| CAS Number | 492-27-3 | Molecular Weight | 189.167 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 358.4±42.0 °C at 760 mmHg | |
| Molecular Formula | C10H7NO3 | Melting Point | 275 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 170.5±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Lipocalin 2 modulates the cellular response to amyloid beta.
Cell Death Differ. 21(10) , 1588-99, (2014) The production, accumulation and aggregation of amyloid beta (Aβ) peptides in Alzheimer's disease (AD) are influenced by different modulators. Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyloid precur... |
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From Memory Impairment to Posttraumatic Stress Disorder-Like Phenotypes: The Critical Role of an Unpredictable Second Traumatic Experience.
J. Neurosci. 35 , 15903-15, (2015) Arousal and stress critically regulate memory formation and retention. Increasing levels of stress produce an inverted U-shaped effect on cognitive performance, including the retention of explicit memories, and experiencing a severe stress during a traumatic ... |
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Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes.
J. Nutr. 145(1) , 87-95, (2015) The use of oral contraceptives (OCs) has been associated with low plasma pyridoxal 5'-phosphate (PLP). The functional consequences are unclear.To determine whether functional vitamin B-6 insufficiency occurs in OC users and is attributable to OCs, we investig... |
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Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats.
Biosci. Biotechnol. Biochem. 79(1) , 103-8, (2015) The conversion of tryptophan (Trp) → nicotinamide (Nam) is an important pathway for supplying vitamin niacin. We reported the following two phenomena: (1) severe food restriction led to an increase in the Trp → Nam conversion compared with free-access control... |
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Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.
J. Nutr. Sci. Vitaminol. 60(4) , 255-60, (2014) We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-control... |
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Connecting inflammation with glutamate agonism in suicidality.
Biol. Psychiatry 38(5) , 743-52, (2013) The NMDA-receptor antagonist ketamine has proven efficient in reducing symptoms of suicidality, although the mechanisms explaining this effect have not been detailed in psychiatric patients. Recent evidence points towards a low-grade inflammation in brains of... |
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The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
J. Nutr. 143(7) , 1046-51, (2013) In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO). We aimed to determine whether tdo-knockout (td... |
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Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid.
Biochem. Soc. Trans. 21(1) , 83-9, (1993)
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Quinolinic acid and kynurenic acid in the mammalian brain.
Adv. Exp. Med. Biol. 294 , 185-99, (1991)
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Behavioral Deficits Are Accompanied by Immunological and Neurochemical Changes in a Mouse Model for Neuropsychiatric Lupus (NP-SLE).
Int. J. Mol. Sci. 16 , 15150-71, (2015) Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) have been understudied compared to end-organ failure and peripheral pathology. Neuropsychiatric symptoms, particularly affective and cognitive indications, may be among the earliest manifestat... |