Thiazole Orange
Thiazole Orange structure
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Common Name | Thiazole Orange | ||
|---|---|---|---|---|
| CAS Number | 107091-89-4 | Molecular Weight | 476.610 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H24N2O3S2 | Melting Point | 270ºC (dec.)(lit.) | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Erythroferrone contributes to recovery from anemia of inflammation.
Blood 124(16) , 2569-74, (2014) Erythroferrone (ERFE) is an erythropoiesis-driven regulator of iron homeostasis. ERFE mediates the suppression of the iron-regulatory hormone hepcidin to increase iron absorption and mobilization of iron from stores. We examined the role of ERFE in the recove... |
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Isocitrate treatment of acute anemia of inflammation in a mouse model.
Blood Cells Mol. Dis. 56 , 31-6, (2015) Acute and severe anemia of inflammation (AI) is a common complication of various clinical syndromes, including fulminant infections, critical illness with multiorgan failure, and exacerbations of autoimmune diseases. Building on recent data showing beneficial... |
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Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.
Sci. Rep. 5 , 17316, (2015) The mitogen- and stress-activated kinase MSK1/2 plays a decisive role in apoptosis. In analogy to apoptosis of nucleated cells, suicidal erythrocyte death called eryptosis is characterized by cell shrinkage and cell membrane scrambling leading to phosphatidyl... |
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Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.
Malaria Journal 14 , 213, (2015) The discovery of malaria transmission-blocking compounds is seen as key to malaria elimination strategies and gametocyte-screening platforms are critical filters to identify active molecules. However, unlike asexual parasite assays measuring parasite prolifer... |
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Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice.
J. Lipid Res. 56 , 1282-95, (2015) LCAT, a plasma enzyme that esterifies cholesterol, has been proposed to play an antiatherogenic role, but animal and epidemiologic studies have yielded conflicting results. To gain insight into LCAT and the role of free cholesterol (FC) in atherosclerosis, we... |
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Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia.
Blood 123(25) , 3864-72, (2014) In β-thalassemia, unequal production of α- and β-globin chains in erythroid precursors causes apoptosis and inhibition of late-stage erythroid differentiation, leading to anemia, ineffective erythropoiesis (IE), and dysregulated iron homeostasis. Here we used... |
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HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis.
J. Mol. Med. 93(8) , 857-66, (2015) During prolonged hypoxia, hypoxia-inducible factors (HIFs) mediate an increase in erythropoiesis, leading to an increased red blood cell (RBC) mass and polycythemia. Upon return to normoxia, the increased RBC mass is abruptly overcorrected by the preferential... |
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A novel micronucleus in vitro assay utilizing human hematopoietic stem cells.
Toxicol. In Vitro 29 , 1897-905, (2015) The induction of micronucleated reticulocytes in the bone marrow is a sensitive indicator of chromosomal damage. Therefore, the micronucleus assay in rodents is widely used in genotoxicity and carcinogenicity testing. A test system based on cultured human pri... |
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Aptamer-based microchip electrophoresis assays for amplification detection of carcinoembryonic antigen.
Clin. Chim. Acta 450 , 304-9, (2015) Carcinoembryonic antigen (CEA) as one of the most widely used tumor markers is used in the clinical diagnosis of colorectal, pancreatic, gastric, and cervical carcinomas. We developed an aptamer-based microchip electrophoresis assay technique for assaying CEA... |
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Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation.
Cell Cycle 14 , 3248-60, (2015) PARP inhibitors have been approved for treatment of tumors with mutations in or loss of BRCA1/2. The molecular mechanisms and particularly the cellular phenotypes resulting in synthetic lethality are not well understood and varying clinical responses have bee... |