Reveromycin A
Reveromycin A structure
|
Common Name | Reveromycin A | ||
|---|---|---|---|---|
| CAS Number | 134615-37-5 | Molecular Weight | 660.79100 | |
| Density | 1.21g/cm3 | Boiling Point | 849ºC at 760mmHg | |
| Molecular Formula | C36H52O11 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 258.7ºC | |
|
Development and application of bioprobes for Mammalian cell cycle analyses.
Curr. Med. Chem. 10(9) , 727-32, (2003) In this review, I have mainly described the cell cycle inhibitors isolated from microbial metabolites. Once the molecular target of the inhibitor is determined, the inhibitor can be used as bioprobe to dissect the diverse aspect of biological functions in che... |
|
|
Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases.
Cancer Sci. 100(11) , 1999-2005, (2009) Osteoclasts are highly specialized cells that resorb bone, and their abnormal activity is implicated in a variety of human bone diseases. In neoplastic bone metastasis, the bone destruction caused by osteoclasts is not only associated with the formation and p... |
|
|
Synthesis and biological activities of reveromycin A and spirofungin A derivatives.
Bioorg. Med. Chem. Lett. 18(13) , 3756-60, (2008) Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the... |
|
|
Pharmacological topics of bone metabolism: antiresorptive microbial compounds that inhibit osteoclast differentiation, function, and survival.
J. Pharmacol. Sci. 106(4) , 547-54, (2008) The mass and function of bones depends on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Osteoporosis typically reflects an imbalance in skeletal turnover, such that bone resorption... |
|
|
Creation of novel reveromycin derivatives by alcohol-added fermentation.
J. Antibiot. 66(4) , 247-50, (2013)
|
|
|
Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice.
Am. J. Orthod. Dentofacial Orthop. 144(3) , 368-80, (2013) In this study, mechanical stress in the form of tooth movement was applied to osteoprotegerin-deficient knockout mice, which served as an animal model for juvenile Paget's disease. To compare and evaluate bone turnover and response of the surrounding bony tis... |
|
|
Inhibitory action of reveromycin A on TGF-alpha-dependent growth of ovarian carcinoma BG-1 in vitro and in vivo.
Oncol. Res. 9(1) , 7-11, (1997) The antitumor effect of reveromycin A (RM-A), an inhibitor of EGF-dependent cell proliferation on murine and human tumor cell lines, was examined in vitro and in vivo, RM-A showed little antitumor effect against three murine tumors tested, but showed strong a... |
|
|
Biosynthesis: a twist in the tail.
Nat. Chem. Biol. 7(7) , 409-11, (2011)
|
|
|
Industrial microbiology and biotechnology - 2006 Annual Meeting.
IDrugs 9(10) , 690-2, (2006)
|
|
|
Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.
Proc. Natl. Acad. Sci. U. S. A. 103(12) , 4729-34, (2006) Mature bone-resorbing osteoclasts (OCs) mediate excessive bone loss seen in several bone disorders, including osteoporosis. Here, we showed that reveromycin A (RM-A), a small natural product with three carboxylic groups in its structure, induced apoptosis spe... |